Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 830957..831486 Replicon chromosome
Accession NZ_CP066376
Organism Staphylococcus epidermidis strain PH1-28

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag ICN77_RS04550 Protein ID WP_001829891.1
Coordinates 831124..831486 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag ICN77_RS04545 Protein ID WP_001829931.1
Coordinates 830957..831127 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN77_RS04520 826781..827260 + 480 WP_002503645.1 PH domain-containing protein -
ICN77_RS04525 827253..828758 + 1506 WP_002503644.1 PH domain-containing protein -
ICN77_RS04530 828745..829254 + 510 WP_002503643.1 PH domain-containing protein -
ICN77_RS04535 829302..829655 + 354 WP_002457108.1 holo-ACP synthase -
ICN77_RS04540 829722..830870 + 1149 WP_002457107.1 alanine racemase -
ICN77_RS04545 830957..831127 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ICN77_RS04550 831124..831486 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ICN77_RS04555 831831..832832 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
ICN77_RS04560 832932..833258 + 327 WP_001829952.1 anti-sigma factor antagonist -
ICN77_RS04565 833260..833739 + 480 WP_001829903.1 anti-sigma B factor RsbW -
ICN77_RS04570 833714..834484 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T184378 WP_001829891.1 NZ_CP066376:831124-831486 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T184378 NZ_CP087634:330518-330886 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT184378 WP_001829931.1 NZ_CP066376:830957-831127 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT184378 NZ_CP087634:330300-330521 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References