Detailed information of TA system TA184377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 819772..820281
• Replicon: chromosome
• Accession: NZ_CP066376
• Organism: Staphylococcus epidermidis strain PH1-28

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: ICN77_RS04490
• Protein ID: WP_198895857.1
• Coordinates: 820072..820281 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: Q5HMD4
• Locus tag: ICN77_RS04485
• Protein ID: WP_001829893.1
• Coordinates: 819772..820065 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICN77_RS04460	814780..815568	+	789	WP_001829971.1	hydroxyethylthiazole kinase	-
ICN77_RS04465	815574..816212	+	639	WP_002505076.1	thiamine phosphate synthase	-
ICN77_RS04470	816301..817173	+	873	WP_002458703.1	membrane protein insertase YidC	-
ICN77_RS04475	817279..817932	-	654	WP_001829983.1	HD domain-containing protein	-
ICN77_RS04480	818114..819598	-	1485	WP_002457116.1	cardiolipin synthase	-
ICN77_RS04485	819772..820065	+	294	WP_001829893.1	copper-sensing transcriptional repressor CsoR	Antitoxin
ICN77_RS04490	820072..820281	+	210	WP_198895857.1	heavy-metal-associated domain-containing protein	Toxin
ICN77_RS04495	820424..820561	+	138	WP_001829949.1	hypothetical protein	-
ICN77_RS04500	820660..821871	-	1212	WP_002486299.1	rod shape-determining protein RodA	-
ICN77_RS04505	822262..823335	+	1074	WP_198895858.1	D-alanine--D-alanine ligase	-
ICN77_RS04510	823347..824702	+	1356	WP_002457113.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (4-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7975.18 Da
• Isoelectric Point: 7.0080

>T184377 WP_198895857.1 NZ_CP066376:820072-820281 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNETRVEFDTPANLNNIEKEIYDYGFRIL

Nucleotide

• Length: 210 bp

>T184377 NZ_CP087633:c2724-2458 [Klebsiella pneumoniae subsp. pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11070.65 Da
• Isoelectric Point: 5.5778

>AT184377 WP_001829893.1 NZ_CP066376:819772-820065 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT184377 NZ_CP087633:c2932-2708 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0N1EPA7