Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3882514..3884055 Replicon chromosome
Accession NZ_CP066369
Organism Shewanella putrefaciens strain CGMCC-1.6515

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JFT56_RS16970 Protein ID WP_198781163.1
Coordinates 3882514..3883815 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JFT56_RS16975 Protein ID WP_198781164.1
Coordinates 3883819..3884055 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFT56_RS16945 3877987..3878283 - 297 WP_198783622.1 DUF134 domain-containing protein -
JFT56_RS16950 3878450..3879940 - 1491 WP_198781159.1 ATP-binding cassette domain-containing protein -
JFT56_RS16955 3880215..3880466 + 252 WP_198781160.1 DUF2999 domain-containing protein -
JFT56_RS16960 3880665..3881228 + 564 WP_198781161.1 hypothetical protein -
JFT56_RS16965 3881262..3882221 - 960 WP_198781162.1 hypothetical protein -
JFT56_RS16970 3882514..3883815 - 1302 WP_198781163.1 HipA domain-containing protein Toxin
JFT56_RS16975 3883819..3884055 - 237 WP_198781164.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JFT56_RS16980 3884891..3885697 + 807 WP_198783623.1 NYN domain-containing protein -
JFT56_RS16985 3885906..3886676 + 771 WP_198781165.1 hypothetical protein -
JFT56_RS16990 3886666..3888159 + 1494 WP_198781166.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48780.13 Da        Isoelectric Point: 5.1952

>T184371 WP_198781163.1 NZ_CP066369:c3883815-3882514 [Shewanella putrefaciens]
MSTAKTLTLEMYLGDLIIGELSFDSTTDTFAVHYTEKWQQSGFPLSPTIPLNGTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQMRPIMAAEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGRYKALCVERFDRRYMASEQRVLRRHIVD
SCQALGFSVSKKYERNFGTGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWALFNLLSGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQELAMAIDDEFDPNSIYAYQFAAFIDGLGLPRSLLISNLTRMTRRISQLIDEVISILPPLD
EDEAVFVAHYKALLLARCERYLSMTAEVRDVEV

Download         Length: 1302 bp

>T184371 NZ_CP087629:c5011386-5010469 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8527.90 Da        Isoelectric Point: 6.2232

>AT184371 WP_198781164.1 NZ_CP066369:c3884055-3883819 [Shewanella putrefaciens]
MALPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSAQTSDTETNGWY

Download         Length: 237 bp

>AT184371 NZ_CP087629:c5012150-5011392 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References