Detailed information of TA system TA184369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 387717..389290
• Replicon: chromosome
• Accession: NZ_CP066369
• Organism: Shewanella putrefaciens strain CGMCC-1.6515

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JFT56_RS01730
• Protein ID: WP_198782026.1
• Coordinates: 387717..389024 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JFT56_RS01735
• Protein ID: WP_198782027.1
• Coordinates: 389024..389290 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFT56_RS01710	383549..384445	-	897	WP_198782023.1	sulfotransferase family protein	-
JFT56_RS01715	384759..385874	+	1116	WP_198782024.1	Fic family protein	-
JFT56_RS01720	386162..387460	+	1299	WP_198782025.1	restriction endonuclease	-
JFT56_RS01725	387465..387704	-	240	Protein_328	LysR family transcriptional regulator	-
JFT56_RS01730	387717..389024	-	1308	WP_198782026.1	type II toxin-antitoxin system HipA family toxin	Toxin
JFT56_RS01735	389024..389290	-	267	WP_198782027.1	helix-turn-helix domain-containing protein	Antitoxin
JFT56_RS01740	389603..390499	-	897	WP_198782028.1	LysR family transcriptional regulator	-
JFT56_RS01745	390898..391581	+	684	WP_198782029.1	pyrimidine 5'-nucleotidase	-
JFT56_RS01750	391610..392248	-	639	WP_198782030.1	multidrug MFS transporter	-
JFT56_RS01755	392619..393254	+	636	Protein_334	MarC family NAAT transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 49094.37 Da
• Isoelectric Point: 6.7360

>T184369 WP_198782026.1 NZ_CP066369:c389024-387717 [Shewanella putrefaciens]
MAALDVYMNGFLVGVFSKEETGAHRFQYNADWLATPGARPISLSMPLRQRHYQGDEVYNFFDNLLPDSTEIRQRILARHH
ASSTQPFDLLTKVGQDSVGALQLVPQGIEPRDIKKIECEPLDDLALTRVLAGYQSKIPLGMLEEYDDFRISVAGAQEKTA
LLKYDGQWCLPHGSTPTSHIIKLPIGQITTHSHTLDLSDSVENEYLCMSIAREYGLPVPDCEILKVGNIKALAVERFDRR
YAADNSWLMRLPQEDFCQTLNIPSARKYENQGGPGISEIMYVLMGSLAPERDRRIFMKAQVLFWLLAATDGHAKNFSLFI
RPEGKYELTPLYDIISVYPVLGGTGLNIRDAKLAMGLSATKGKKYQIEQIFPRHFLATANQVGFSQHAMNELLEEFVKKT
PMVIQRAQAQLPDDFPPHIQHSILSGLEHRVRRLL

Nucleotide

• Length: 1308 bp

>T184369 NZ_CP087629:c4751525-4750992 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9949.09 Da
• Isoelectric Point: 5.0651

>AT184369 WP_198782027.1 NZ_CP066369:c389290-389024 [Shewanella putrefaciens]
MKITTTKQLSAYIQDVRQSQGLSQAKIGEKIGLRQGTISNFEQNPDSTKLDTFFKLISALELEIELKPRNASDSDTGTSD
NKQWTQEW

Nucleotide

• Length: 267 bp

>AT184369 NZ_CP087629:c4751802-4751536 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA