Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 57336..57858 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP066368 | ||
| Organism | Escherichia coli strain AR Bank #0346 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | FNX50_RS23645 | Protein ID | WP_000638823.1 |
| Coordinates | 57336..57617 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | FNX50_RS23650 | Protein ID | WP_000121741.1 |
| Coordinates | 57607..57858 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNX50_RS23610 (FNX50_23610) | 53485..53805 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| FNX50_RS24060 | 53876..54166 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| FNX50_RS23620 (FNX50_23620) | 54166..54750 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| FNX50_RS23625 (FNX50_23625) | 54771..55169 | - | 399 | WP_072643816.1 | hypothetical protein | - |
| FNX50_RS23630 (FNX50_23630) | 55288..55725 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| FNX50_RS23635 (FNX50_23635) | 55731..56966 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| FNX50_RS23640 (FNX50_23640) | 56969..57268 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| FNX50_RS23645 (FNX50_23645) | 57336..57617 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FNX50_RS23650 (FNX50_23650) | 57607..57858 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| FNX50_RS23655 (FNX50_23655) | 57958..58593 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| FNX50_RS23660 (FNX50_23660) | 58666..58953 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| FNX50_RS23665 (FNX50_23665) | 58966..59220 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| FNX50_RS23670 (FNX50_23670) | 59222..59863 | - | 642 | WP_001425343.1 | type IV secretion system protein | - |
| FNX50_RS23675 (FNX50_23675) | 59869..60864 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| FNX50_RS23680 (FNX50_23680) | 60868..61125 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| FNX50_RS23685 (FNX50_23685) | 61122..61424 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| FNX50_RS23690 | 61405..61662 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| FNX50_RS23695 (FNX50_23690) | 61695..62141 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| FNX50_RS23700 (FNX50_23695) | 62152..62322 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| FNX50_RS23705 (FNX50_23700) | 62326..62769 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-55 / mcr-1.1 | - | 1..66038 | 66038 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T184366 WP_000638823.1 NZ_CP066368:c57617-57336 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T184366 NZ_CP087629:2001296-2001398 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT184366 WP_000121741.1 NZ_CP066368:c57858-57607 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT184366 NZ_CP087629:c2001405-2001260 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|