Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 12390..12891 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP066368 | ||
| Organism | Escherichia coli strain AR Bank #0346 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | FNX50_RS23405 | Protein ID | WP_000702247.1 |
| Coordinates | 12390..12650 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | FNX50_RS23410 | Protein ID | WP_001132407.1 |
| Coordinates | 12640..12891 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNX50_RS23375 (FNX50_23370) | 8513..9774 | - | 1262 | Protein_13 | IS1380-like element ISEcp1 family transposase | - |
| FNX50_RS23380 (FNX50_23375) | 10533..10862 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| FNX50_RS23385 (FNX50_23380) | 10971..11117 | - | 147 | WP_001356709.1 | hypothetical protein | - |
| FNX50_RS23390 (FNX50_23385) | 11443..11766 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| FNX50_RS23395 (FNX50_23390) | 11808..12017 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| FNX50_RS23400 (FNX50_23395) | 12114..12338 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| FNX50_RS23405 (FNX50_23400) | 12390..12650 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| FNX50_RS23410 (FNX50_23405) | 12640..12891 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| FNX50_RS23415 (FNX50_23410) | 13441..13719 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| FNX50_RS23420 (FNX50_23415) | 14139..14405 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| FNX50_RS24055 | 14512..14955 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| FNX50_RS23430 (FNX50_23425) | 15252..15434 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| FNX50_RS23435 (FNX50_23430) | 15459..15896 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| FNX50_RS23440 (FNX50_23435) | 16027..16353 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| FNX50_RS23445 (FNX50_23440) | 16373..17080 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| FNX50_RS23450 (FNX50_23445) | 17082..17834 | - | 753 | WP_063078685.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-55 / mcr-1.1 | - | 1..66038 | 66038 | |
| - | flank | IS/Tn | blaCTX-M-55 | - | 7385..9774 | 2389 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T184365 WP_000702247.1 NZ_CP066368:12390-12650 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T184365 NZ_CP087629:849407-849814 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT184365 WP_001132407.1 NZ_CP066368:12640-12891 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT184365 NZ_CP087629:849160-849426 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|