Detailed information of TA system TA184317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1702590..1703124
• Replicon: plasmid pSymB
• Accession: NZ_CP066358
• Organism: Sinorhizobium meliloti strain AK76

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JFX10_RS07685
• Protein ID: WP_017268214.1
• Coordinates: 1702590..1702886 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JFX10_RS07690
• Protein ID: WP_127637095.1
• Coordinates: 1702876..1703124 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFX10_RS07655	1698179..1699558	-	1380	WP_027988292.1	sodium:alanine symporter family protein	-
JFX10_RS07660	1700092..1700301	-	210	WP_003527838.1	dodecin family protein	-
JFX10_RS07665	1700591..1701037	+	447	WP_014527651.1	DNA-binding protein	-
JFX10_RS07670	1701041..1701226	-	186	WP_014527652.1	hypothetical protein	-
JFX10_RS07675	1701393..1701791	-	399	WP_010974988.1	hypothetical protein	-
JFX10_RS07680	1702251..1702511	+	261	Protein_1532	helix-turn-helix domain-containing protein	-
JFX10_RS07685	1702590..1702886	-	297	WP_017268214.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFX10_RS07690	1702876..1703124	-	249	WP_127637095.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
JFX10_RS07695	1703743..1703868	+	126	Protein_1535	IS481 family transposase	-
JFX10_RS07700	1703952..1704746	-	795	WP_198868555.1	methyltransferase domain-containing protein	-
JFX10_RS07705	1704750..1705550	-	801	WP_127623684.1	ABC transporter ATP-binding protein	-
JFX10_RS07710	1705547..1706590	-	1044	WP_198868556.1	iron ABC transporter permease	-
JFX10_RS07715	1706587..1707654	-	1068	WP_010974979.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	htpB	1..1719217	1719217
	-	flank	IS/Tn	-	-	1703677..1703868	191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-93)

Antitoxin

• Antitoxin ParD (5-72)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11490.20 Da
• Isoelectric Point: 10.7543

>T184317 WP_017268214.1 NZ_CP066358:c1702886-1702590 [Sinorhizobium meliloti]
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL

Nucleotide

• Length: 297 bp

>T184317 NZ_CP087611:c4929484-4928567 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8910.78 Da
• Isoelectric Point: 4.4098

>AT184317 WP_127637095.1 NZ_CP066358:c1703124-1702876 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GH

Nucleotide

• Length: 249 bp

>AT184317 NZ_CP087611:c4930248-4929490 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA