184316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1360499..1361166 Replicon plasmid pSymB
Accession NZ_CP066358
Organism Sinorhizobium meliloti strain AK76

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B3N559
Locus tag JFX10_RS06050 Protein ID WP_017266625.1
Coordinates 1360723..1361166 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag JFX10_RS06045 Protein ID WP_010975287.1
Coordinates 1360499..1360726 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX10_RS06025 1355892..1356773 - 882 WP_013849975.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
JFX10_RS06030 1356891..1358183 - 1293 WP_013849976.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
JFX10_RS06035 1358553..1359842 + 1290 WP_015008544.1 SDR family oxidoreductase -
JFX10_RS06040 1359842..1360315 + 474 WP_015008545.1 DUF2269 family protein -
JFX10_RS06045 1360499..1360726 + 228 WP_010975287.1 hypothetical protein Antitoxin
JFX10_RS06050 1360723..1361166 + 444 WP_017266625.1 PIN domain-containing protein Toxin
JFX10_RS06055 1361182..1362120 - 939 WP_013849980.1 choline ABC transporter substrate-binding protein -
JFX10_RS06060 1362189..1363019 - 831 WP_013849981.1 SDR family oxidoreductase -
JFX10_RS06065 1363016..1363513 - 498 WP_017270158.1 acetone carboxylase subunit gamma -
JFX10_RS06070 1363517..1365709 - 2193 WP_013849983.1 hydantoinase B/oxoprolinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..1719217 1719217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15638.95 Da        Isoelectric Point: 6.6378

>T184316 WP_017266625.1 NZ_CP066358:1360723-1361166 [Sinorhizobium meliloti]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASMGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPVMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

>T184316 NZ_CP087611:c4772000-4771716 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT184316 WP_010975287.1 NZ_CP066358:1360499-1360726 [Sinorhizobium meliloti]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp

>AT184316 NZ_CP087611:c4772232-4771990 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3N559

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References