Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 7445462..7446135 Replicon chromosome
Accession NZ_CP066356
Organism Bradyrhizobium elkanii USDA 76

Toxin (Protein)


Gene name vapC Uniprot ID A0A7S7Q6D3
Locus tag JEY66_RS35305 Protein ID WP_016846333.1
Coordinates 7445713..7446135 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7S7Q682
Locus tag JEY66_RS35300 Protein ID WP_016846334.1
Coordinates 7445462..7445716 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JEY66_RS35290 (JEY66_35110) 7441461..7444424 - 2964 WP_129964842.1 hypothetical protein -
JEY66_RS35295 (JEY66_35115) 7444529..7444852 - 324 WP_240537168.1 DUF3883 domain-containing protein -
JEY66_RS35300 (JEY66_35120) 7445462..7445716 + 255 WP_016846334.1 plasmid stabilization protein Antitoxin
JEY66_RS35305 (JEY66_35125) 7445713..7446135 + 423 WP_016846333.1 type II toxin-antitoxin system VapC family toxin Toxin
JEY66_RS35310 (JEY66_35130) 7446987..7447319 + 333 WP_016846332.1 hypothetical protein -
JEY66_RS35315 (JEY66_35135) 7447303..7450716 - 3414 WP_233475736.1 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14769.94 Da        Isoelectric Point: 7.3188

>T184313 WP_016846333.1 NZ_CP066356:7445713-7446135 [Bradyrhizobium elkanii USDA 76]
VILLDTNVVSEAMKPEPHPSVRHWLDAQAAETVFLSSVTVAELLFGIGALPRGRRKDRLAVALDGVLDLFTARILPFDTA
AARRYAELAVKARAAGKGFPTPDGYIAAIAAAHGFAVASRDTSAFNAAGLTIIDPWTATS

Download         Length: 423 bp

>T184313 NZ_CP087611:4010724-4010942 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9276.61 Da        Isoelectric Point: 9.0496

>AT184313 WP_016846334.1 NZ_CP066356:7445462-7445716 [Bradyrhizobium elkanii USDA 76]
MAAVTIRNLSEEAHRALKVRAAQHNRSAEAEMRAILEAAVRPQGRLRLGTALSEMSRKIGLTNADVEALEHGRDVRPAEP
MHLE

Download         Length: 255 bp

>AT184313 NZ_CP087611:4010323-4010697 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S7Q6D3

Antitoxin

Source ID Structure
AlphaFold DB A0A7S7Q682

References