Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5289439..5290106 Replicon chromosome
Accession NZ_CP066343
Organism Xanthomonas citri pv. durantae strain LMG696

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag Xdur_RS22940 Protein ID WP_005916679.1
Coordinates 5289690..5290106 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag Xdur_RS22935 Protein ID WP_005916676.1
Coordinates 5289439..5289693 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Xdur_RS22910 (Xdur_022835) 5285589..5285768 + 180 WP_011052886.1 RNA 2'-phosphotransferase -
Xdur_RS22915 (Xdur_022840) 5285937..5287202 + 1266 WP_015463799.1 phospholipase D-like domain-containing protein -
Xdur_RS22920 (Xdur_022845) 5287228..5287755 - 528 WP_005916668.1 hypothetical protein -
Xdur_RS22925 (Xdur_022850) 5287994..5288200 + 207 WP_003489327.1 hypothetical protein -
Xdur_RS22930 (Xdur_022855) 5288187..5289293 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
Xdur_RS22935 (Xdur_022860) 5289439..5289693 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
Xdur_RS22940 (Xdur_022865) 5289690..5290106 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
Xdur_RS22945 (Xdur_022870) 5290228..5290500 - 273 WP_125459513.1 hypothetical protein -
Xdur_RS22950 (Xdur_022875) 5290559..5290771 - 213 WP_015472901.1 hypothetical protein -
Xdur_RS22955 (Xdur_022880) 5291028..5292647 + 1620 WP_015463800.1 alpha/beta hydrolase-fold protein -
Xdur_RS22960 (Xdur_022885) 5292751..5293149 - 399 WP_004429277.1 DUF2384 domain-containing protein -
Xdur_RS22965 (Xdur_022890) 5293465..5293896 + 432 WP_005922907.1 hypothetical protein -
Xdur_RS22970 (Xdur_022895) 5293925..5294155 - 231 WP_223293191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T184305 WP_005916679.1 NZ_CP066343:5289690-5290106 [Xanthomonas citri pv. durantae]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T184305 NZ_CP087609:1017-1331 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT184305 WP_005916676.1 NZ_CP066343:5289439-5289693 [Xanthomonas citri pv. durantae]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT184305 NZ_CP087609:751-1029 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References