Detailed information of TA system TA184305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 5289439..5290106
• Replicon: chromosome
• Accession: NZ_CP066343
• Organism: Xanthomonas citri pv. durantae strain LMG696

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M4U0C6
• Locus tag: Xdur_RS22940
• Protein ID: WP_005916679.1
• Coordinates: 5289690..5290106 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4U000
• Locus tag: Xdur_RS22935
• Protein ID: WP_005916676.1
• Coordinates: 5289439..5289693 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Xdur_RS22910 (Xdur_022835)	5285589..5285768	+	180	WP_011052886.1	RNA 2'-phosphotransferase	-
Xdur_RS22915 (Xdur_022840)	5285937..5287202	+	1266	WP_015463799.1	phospholipase D-like domain-containing protein	-
Xdur_RS22920 (Xdur_022845)	5287228..5287755	-	528	WP_005916668.1	hypothetical protein	-
Xdur_RS22925 (Xdur_022850)	5287994..5288200	+	207	WP_003489327.1	hypothetical protein	-
Xdur_RS22930 (Xdur_022855)	5288187..5289293	+	1107	WP_005916674.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Xdur_RS22935 (Xdur_022860)	5289439..5289693	+	255	WP_005916676.1	Arc family DNA-binding protein	Antitoxin
Xdur_RS22940 (Xdur_022865)	5289690..5290106	+	417	WP_005916679.1	type II toxin-antitoxin system VapC family toxin	Toxin
Xdur_RS22945 (Xdur_022870)	5290228..5290500	-	273	WP_125459513.1	hypothetical protein	-
Xdur_RS22950 (Xdur_022875)	5290559..5290771	-	213	WP_015472901.1	hypothetical protein	-
Xdur_RS22955 (Xdur_022880)	5291028..5292647	+	1620	WP_015463800.1	alpha/beta hydrolase-fold protein	-
Xdur_RS22960 (Xdur_022885)	5292751..5293149	-	399	WP_004429277.1	DUF2384 domain-containing protein	-
Xdur_RS22965 (Xdur_022890)	5293465..5293896	+	432	WP_005922907.1	hypothetical protein	-
Xdur_RS22970 (Xdur_022895)	5293925..5294155	-	231	WP_223293191.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-127)

Antitoxin

• Arc-like DNA binding domain (1-39)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14795.09 Da
• Isoelectric Point: 5.6920

>T184305 WP_005916679.1 NZ_CP066343:5289690-5290106 [Xanthomonas citri pv. durantae]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Nucleotide

• Length: 417 bp

>T184305 NZ_CP087609:1017-1331 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8996.53 Da
• Isoelectric Point: 11.3362

>AT184305 WP_005916676.1 NZ_CP066343:5289439-5289693 [Xanthomonas citri pv. durantae]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Nucleotide

• Length: 255 bp

>AT184305 NZ_CP087609:751-1029 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Structures

Toxin

• AlphaFold DB: M4U0C6

Antitoxin

• AlphaFold DB: A0A828YKJ0