Detailed information of TA system TA184301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 99452..99996
• Replicon: chromosome
• Accession: NZ_CP066343
• Organism: Xanthomonas citri pv. durantae strain LMG696

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8FI26
• Locus tag: Xdur_RS00430
• Protein ID: WP_003487886.1
• Coordinates: 99697..99996 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8FI25
• Locus tag: Xdur_RS00425
• Protein ID: WP_003487884.1
• Coordinates: 99452..99709 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Xdur_RS00410 (Xdur_000410)	94535..96052	-	1518	WP_078516351.1	ribonuclease H-like domain-containing protein	-
Xdur_RS00415 (Xdur_000415)	96049..98544	-	2496	WP_015462699.1	DEAD/DEAH box helicase	-
Xdur_RS00420 (Xdur_000420)	98722..99384	+	663	WP_005912558.1	hemolysin III family protein	-
Xdur_RS00425 (Xdur_000425)	99452..99709	+	258	WP_003487884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Xdur_RS00430 (Xdur_000430)	99697..99996	+	300	WP_003487886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Xdur_RS00440 (Xdur_000440)	100176..101075	-	900	WP_011050073.1	SDR family NAD(P)-dependent oxidoreductase	-
Xdur_RS00445 (Xdur_000445)	101136..101873	-	738	WP_003487890.1	SDR family oxidoreductase	-
Xdur_RS00450 (Xdur_000450)	101999..102910	+	912	WP_011050074.1	LysR family transcriptional regulator	-
Xdur_RS00455 (Xdur_000455)	103076..104149	-	1074	WP_040107715.1	ATP-grasp fold amidoligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11231.97 Da
• Isoelectric Point: 9.7235

>T184301 WP_003487886.1 NZ_CP066343:99697-99996 [Xanthomonas citri pv. durantae]
MAEIIWSVPALADLDAIADYIAIDNAPAAAALVKRVFGHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRI
VVVHVMRSERALRGNRLSR

Nucleotide

• Length: 300 bp

>T184301 NZ_CP087606:c5428298-5427915 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9683.21 Da
• Isoelectric Point: 9.8274

>AT184301 WP_003487884.1 NZ_CP066343:99452-99709 [Xanthomonas citri pv. durantae]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARHRM
ARWLK

Nucleotide

• Length: 258 bp

>AT184301 NZ_CP087606:c5428540-5428298 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: H8FI26

Antitoxin

• AlphaFold DB: H8FI25