Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4803146..4803773 Replicon chromosome
Accession NZ_CP066339
Organism Alicyclobacillus sp. SO9

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag GI364_RS22415 Protein ID WP_198851387.1
Coordinates 4803146..4803496 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GI364_RS22420 Protein ID WP_198851388.1
Coordinates 4803501..4803773 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GI364_RS22385 4798738..4799364 + 627 WP_198851382.1 DedA family protein -
GI364_RS22390 4799448..4799699 + 252 WP_198851383.1 DUF1450 domain-containing protein -
GI364_RS22395 4799845..4800063 - 219 WP_198851384.1 DUF2922 domain-containing protein -
GI364_RS22400 4800193..4800429 - 237 WP_198851385.1 DUF1659 domain-containing protein -
GI364_RS22405 4800910..4801659 - 750 WP_198851386.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
GI364_RS22410 4801715..4802977 - 1263 WP_198854163.1 adenosylhomocysteinase -
GI364_RS22415 4803146..4803496 - 351 WP_198851387.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GI364_RS22420 4803501..4803773 - 273 WP_198851388.1 ribbon-helix-helix protein, CopG family Antitoxin
GI364_RS22425 4803859..4805106 - 1248 WP_198851389.1 alanine racemase -
GI364_RS22430 4805223..4806116 - 894 WP_198851390.1 DUF1648 domain-containing protein -
GI364_RS22435 4806321..4807325 - 1005 WP_198851391.1 outer membrane lipoprotein carrier protein LolA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12933.00 Da        Isoelectric Point: 5.6976

>T184300 WP_198851387.1 NZ_CP066339:c4803496-4803146 [Alicyclobacillus sp. SO9]
MNVKRGDIFFADLSPVVGSEQGGFRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIPADKYGLDRDSVILLEQL
RTIDKQRLTDKITHLDETMMRLVNEGLQISLGMVDF

Download         Length: 351 bp

>T184300 NZ_CP087606:c5048092-5047175 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10240.68 Da        Isoelectric Point: 4.8275

>AT184300 WP_198851388.1 NZ_CP066339:c4803773-4803501 [Alicyclobacillus sp. SO9]
VSANKRIVVYVPQNLLEQVDGVALRENTNRSEVFREAMQMYLSEQRKQDIRALMQQGYVEMARLNLRIASEAFPLEEEAG
GTVERLVSGV

Download         Length: 273 bp

>AT184300 NZ_CP087606:c5048856-5048098 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References