Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3088055..3088712 Replicon chromosome
Accession NZ_CP066315
Organism Providencia rettgeri strain R39

Toxin (Protein)


Gene name cptA Uniprot ID A0A1J0E9L4
Locus tag JFB93_RS14210 Protein ID WP_042845040.1
Coordinates 3088055..3088465 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1J0E9J6
Locus tag JFB93_RS14215 Protein ID WP_042845042.1
Coordinates 3088446..3088712 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFB93_RS14190 3083994..3085727 - 1734 WP_129466205.1 single-stranded-DNA-specific exonuclease RecJ -
JFB93_RS14195 3085737..3086441 - 705 WP_042845413.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JFB93_RS14200 3086463..3087365 - 903 WP_129466206.1 site-specific tyrosine recombinase XerD -
JFB93_RS14205 3087483..3088001 + 519 WP_042845038.1 flavodoxin FldB -
JFB93_RS14210 3088055..3088465 - 411 WP_042845040.1 protein YgfX Toxin
JFB93_RS14215 3088446..3088712 - 267 WP_042845042.1 FAD assembly factor SdhE Antitoxin
JFB93_RS14220 3088962..3089951 + 990 WP_198860828.1 tRNA-modifying protein YgfZ -
JFB93_RS14225 3089963..3090583 + 621 WP_071548274.1 HD domain-containing protein -
JFB93_RS14230 3090738..3091634 + 897 WP_198860829.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15461.25 Da        Isoelectric Point: 10.6538

>T184297 WP_042845040.1 NZ_CP066315:c3088465-3088055 [Providencia rettgeri]
VVLWKSNLSISWKTQFFSTCVHGAVGMFLLVAPWAPAHSMIWLPLLAVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWNIVKAPWLSRYGILLSLEALQGKQQKIHLWVAKDSVSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T184297 NZ_CP087606:4188455-4188673 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10619.16 Da        Isoelectric Point: 4.8780

>AT184297 WP_042845042.1 NZ_CP066315:c3088712-3088446 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLTTNDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT184297 NZ_CP087606:4188054-4188428 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E9J6

References