Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2187218..2188137 Replicon chromosome
Accession NZ_CP066315
Organism Providencia rettgeri strain R39

Toxin (Protein)


Gene name - Uniprot ID A0A1J0E7D4
Locus tag JFB93_RS09905 Protein ID WP_042843809.1
Coordinates 2187218..2187679 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1J0E7A8
Locus tag JFB93_RS09910 Protein ID WP_042843808.1
Coordinates 2187676..2188137 (-) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFB93_RS09880 2182720..2184180 + 1461 WP_042844339.1 AMP nucleosidase -
JFB93_RS09885 2184161..2184730 + 570 WP_198861406.1 GNAT family N-acetyltransferase -
JFB93_RS09890 2184787..2185209 + 423 WP_042843814.1 helix-turn-helix domain-containing protein -
JFB93_RS09895 2185316..2186275 + 960 WP_166684924.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
JFB93_RS09900 2186319..2187209 + 891 WP_042843811.1 LysR family transcriptional regulator -
JFB93_RS09905 2187218..2187679 - 462 WP_042843809.1 RES domain-containing protein Toxin
JFB93_RS09910 2187676..2188137 - 462 WP_042843808.1 DUF2384 domain-containing protein Antitoxin
JFB93_RS09915 2188227..2188694 - 468 WP_042843807.1 DUF1456 family protein -
JFB93_RS09920 2188880..2189194 - 315 WP_042843806.1 AzlD domain-containing protein -
JFB93_RS09925 2189191..2189892 - 702 WP_048607181.1 AzlC family ABC transporter permease -
JFB93_RS09930 2190579..2191220 + 642 WP_048607183.1 leucine efflux protein LeuE -
JFB93_RS09935 2191280..2191738 - 459 WP_042843802.1 GNAT family N-acetyltransferase -
JFB93_RS09940 2192157..2192543 + 387 WP_048607185.1 cytidine deaminase -
JFB93_RS09945 2192567..2193031 + 465 WP_198861407.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17499.99 Da        Isoelectric Point: 6.4846

>T184296 WP_042843809.1 NZ_CP066315:c2187679-2187218 [Providencia rettgeri]
MILYRLIKSDFAHDAWSGQGARLYGGRWNHKGTPAIYTSTSISLAALEILVHINQDTVLNHFTLLSIEINDRYVMKLSVE
HLPDDWQRDPAPTSTMDIGTTWLTNQDSLALIVPSCIIPYEYNAIINPMHPQFQKVTQTIKPLDFAFDPRFNR

Download         Length: 462 bp

>T184296 NZ_CP087606:2271051-2272373 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17086.57 Da        Isoelectric Point: 9.9812

>AT184296 WP_042843808.1 NZ_CP066315:c2188137-2187676 [Providencia rettgeri]
MRNYIPALPTQPTTPPFKPLWRFAGLPAERGIELTHFLRQGLSVTVLDNIQEWSGISKSELLRISGINERNVARRRNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKSMASDWLNHPVKGLGHTRPIELIATESGALEVIDLIGRIEHGVFS

Download         Length: 462 bp

>AT184296 NZ_CP087606:2270785-2271051 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E7D4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E7A8

References