Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 897412..898058 Replicon chromosome
Accession NZ_CP066315
Organism Providencia rettgeri strain R39

Toxin (Protein)


Gene name Hha Uniprot ID A0A1J0E3F0
Locus tag JFB93_RS03840 Protein ID WP_042846891.1
Coordinates 897412..897615 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1J0E3I4
Locus tag JFB93_RS03845 Protein ID WP_042846890.1
Coordinates 897690..898058 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFB93_RS03815 893491..893829 + 339 WP_042846895.1 P-II family nitrogen regulator -
JFB93_RS03820 893840..895123 + 1284 WP_198861146.1 ammonium transporter AmtB -
JFB93_RS03825 895264..896130 - 867 WP_042846893.1 acyl-CoA thioesterase II -
JFB93_RS03830 896370..896828 + 459 WP_166685880.1 YbaY family lipoprotein -
JFB93_RS03840 897412..897615 - 204 WP_042846891.1 hemolysin expression modulator Hha Toxin
JFB93_RS03845 897690..898058 - 369 WP_042846890.1 Hha toxicity modulator TomB Antitoxin
JFB93_RS03850 898588..899958 - 1371 WP_048608373.1 murein transglycosylase D -
JFB93_RS03855 900040..900792 - 753 WP_042846888.1 hydroxyacylglutathione hydrolase -
JFB93_RS03860 900826..901560 + 735 WP_042846887.1 methyltransferase domain-containing protein -
JFB93_RS03865 901557..902027 - 471 WP_042846886.1 ribonuclease HI -
JFB93_RS03870 902082..902843 + 762 WP_042846885.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T184295 WP_042846891.1 NZ_CP066315:c897615-897412 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

>T184295 NZ_CP087606:2049137-2049239 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14123.05 Da        Isoelectric Point: 4.3849

>AT184295 WP_042846890.1 NZ_CP066315:c898058-897690 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSAQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWETMNQNLVSVLDDDLKCLTSKT

Download         Length: 369 bp

>AT184295 NZ_CP087606:c2049246-2049101 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E3I4

References