Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 196204..196793 Replicon plasmid unnamed1
Accession NZ_CP066311
Organism Azotobacter chroococcum strain HR1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GKQ51_RS22860 Protein ID WP_136888061.1
Coordinates 196204..196416 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GKQ51_RS22865 Protein ID WP_090625122.1
Coordinates 196452..196793 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ51_RS22835 191594..191866 + 273 WP_198868139.1 HU family DNA-binding protein -
GKQ51_RS22840 192015..194066 - 2052 WP_198868140.1 VWA domain-containing protein -
GKQ51_RS22845 194059..194595 - 537 WP_090903332.1 RNA polymerase sigma factor -
GKQ51_RS22850 194880..195056 - 177 WP_169531242.1 hypothetical protein -
GKQ51_RS22855 195106..195826 - 721 Protein_211 DNA-binding protein -
GKQ51_RS22860 196204..196416 + 213 WP_136888061.1 type II toxin-antitoxin system HicA family toxin Toxin
GKQ51_RS22865 196452..196793 + 342 WP_090625122.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GKQ51_RS22870 197261..197614 - 354 WP_198868141.1 hypothetical protein -
GKQ51_RS22875 197773..198996 - 1224 WP_136888064.1 tyrosine-type recombinase/integrase -
GKQ51_RS22880 199276..199638 - 363 WP_198868142.1 helix-turn-helix transcriptional regulator -
GKQ51_RS22885 200315..201100 - 786 WP_198868143.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG 1..307780 307780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-67)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8136.33 Da        Isoelectric Point: 10.4561

>T184290 WP_136888061.1 NZ_CP066311:196204-196416 [Azotobacter chroococcum]
MSKNEKLLAKLLNERASFTWQELVTLLSWLGYRQLEGTGSRVKFDNGDPQALINLHRPHPGNELKTYVRR

Download         Length: 213 bp

>T184290 NZ_CP087598:2154167-2154469 [Paracoccus sp. MA]
ATGACCTTTGAGCTTAAGTTCCTGCCATCCGCACTGAAGGAGTGGAAAAAGCTCGGTGCCACGCTTCGGGAGCAGTTTCG
GAAGAAGCTGGCCGAACGTCTGGAGCAGCCCCGTGTTCCTGCTGATGCGCTGCATGGTCTGGAAGATCATTACAAGATCA
AGCTCCGCAGCGCCGGCTACCGACTCGTCTATCGCGTAGAGGATGCAGAAATTACCGTCACAGTGGTCGCAGTTGGTCGT
CGCGAACGAAGCGAGGTGTATAAAGCTGCAAGCGCACGGCGCGATGATCGACCCAAAAGCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12645.09 Da        Isoelectric Point: 5.8866

>AT184290 WP_090625122.1 NZ_CP066311:196452-196793 [Azotobacter chroococcum]
VNNLLQHRGYYGSIEASTEDNCLFGKLLFIRALVNYEGETVAELQAAFREAVNDYLATCQEQGQEPEVPCKGSFNVRIGH
DLHLAASVAANRHRMSLNDLTRQALSEYLQHHG

Download         Length: 342 bp

>AT184290 NZ_CP087598:2153911-2154177 [Paracoccus sp. MA]
ATGACCTTGTGGAGATTGAATATGCAACGTGTTGAAGCCCAGATTGCGGTCAGTGTCTCTGATCTGAAGAAAAGCCCGAC
CGCAATCATGGATCAGGCGCAAGGCGAGGCCGTCGCCGTGCTGAACCACAATCGCGTCATGGCTTATATGGTCCCGGCCG
ATGTTTACGAGGCGATGATGGAGCGGCTGGACGACCTGGCGCTTGTCGATGTCATTAAGGCCCGGGCGGATGAAACGCCG
ATCAGCGTGGGCCTCGATGACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References