Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 41868..42535 Replicon plasmid unnamed1
Accession NZ_CP066311
Organism Azotobacter chroococcum strain HR1

Toxin (Protein)


Gene name vapC Uniprot ID A0A4V5PSQ5
Locus tag GKQ51_RS22040 Protein ID WP_040107414.1
Coordinates 42119..42535 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0C4WT37
Locus tag GKQ51_RS22035 Protein ID WP_040107413.1
Coordinates 41868..42119 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ51_RS22010 37664..38800 - 1137 WP_090943895.1 aldo/keto reductase -
GKQ51_RS22015 38864..39160 - 297 WP_090943892.1 antibiotic biosynthesis monooxygenase -
GKQ51_RS22020 39404..40584 - 1181 Protein_44 LacI family DNA-binding transcriptional regulator -
GKQ51_RS22025 40632..41120 - 489 WP_136888797.1 hypothetical protein -
GKQ51_RS22030 41264..41692 + 429 WP_136888798.1 hypothetical protein -
GKQ51_RS22035 41868..42119 + 252 WP_040107413.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GKQ51_RS22040 42119..42535 + 417 WP_040107414.1 type II toxin-antitoxin system VapC family toxin Toxin
GKQ51_RS22050 44211..45386 - 1176 WP_198868197.1 HNH endonuclease -
GKQ51_RS22055 46090..47202 - 1113 WP_198868198.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG 1..307780 307780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-60)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14971.41 Da        Isoelectric Point: 7.2792

>T184285 WP_040107414.1 NZ_CP066311:42119-42535 [Azotobacter chroococcum]
MFLLDTNVVSELRKAKQGKADAGVVAWAQSVQVGELYLSAISVMELETGVLLRERKDPAQGALLRAWLDQHVLPGFAGRI
LAVDTAVALRCARLHVPNQKSERDALIAATALVHGMTVVTRNVADFEQTGVAMLNPWI

Download         Length: 417 bp

>T184285 NZ_CP087594:1242111-1242293 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9100.39 Da        Isoelectric Point: 6.4559

>AT184285 WP_040107413.1 NZ_CP066311:41868-42119 [Azotobacter chroococcum]
MPTTLSSREFNHDTSRAKKAALTGPVFITDRGKPAHVLLCIEEYQRLTGSQPSIIDILAMPGGEDVEFEAPRATIKTKPV
DFS

Download         Length: 252 bp

>AT184285 NZ_CP087594:1242358-1242762 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATTGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V5PSQ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0C4WT37

References