Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1742722..1743387 Replicon chromosome
Accession NZ_CP066310
Organism Azotobacter chroococcum strain HR1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GKQ51_RS08195 Protein ID WP_198867650.1
Coordinates 1743196..1743387 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GKQ51_RS08190 Protein ID WP_198867649.1
Coordinates 1742722..1743144 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ51_RS08145 1738378..1739028 + 651 WP_198868031.1 hypothetical protein -
GKQ51_RS08150 1739052..1739780 + 729 WP_198868032.1 Replication protein P -
GKQ51_RS08155 1739777..1740088 + 312 WP_198867644.1 hypothetical protein -
GKQ51_RS08160 1740219..1740416 + 198 WP_198868033.1 hypothetical protein -
GKQ51_RS08165 1740566..1740904 + 339 WP_198868034.1 VRR-NUC domain-containing protein -
GKQ51_RS08170 1740927..1741196 + 270 WP_198867645.1 hypothetical protein -
GKQ51_RS08175 1741177..1741485 + 309 WP_198867646.1 hypothetical protein -
GKQ51_RS08180 1741497..1741874 + 378 WP_198867647.1 hypothetical protein -
GKQ51_RS08185 1742185..1742673 + 489 WP_198867648.1 hypothetical protein -
GKQ51_RS08190 1742722..1743144 - 423 WP_198867649.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GKQ51_RS08195 1743196..1743387 - 192 WP_198867650.1 type II toxin-antitoxin system HicA family toxin Toxin
GKQ51_RS08200 1743537..1743860 + 324 WP_198867651.1 phage holin, lambda family -
GKQ51_RS08205 1744117..1744632 + 516 WP_198867652.1 DUF1441 family protein -
GKQ51_RS08210 1744619..1746718 + 2100 WP_198867653.1 phage terminase large subunit family protein -
GKQ51_RS08215 1746718..1746942 + 225 WP_198867654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1725196..1820868 95672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-64)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7195.23 Da        Isoelectric Point: 10.4725

>T184281 WP_198867650.1 NZ_CP066310:c1743387-1743196 [Azotobacter chroococcum]
MKYSEFRRWLEAQGVEFTKSRGGSSHFKIKAPNGKQTIFPYHGAKEIGEGLRKDIIKQLGLND

Download         Length: 192 bp

>T184281 NZ_CP087593:c2275006-2274902 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15210.41 Da        Isoelectric Point: 6.8433

>AT184281 WP_198867649.1 NZ_CP066310:c1743144-1742722 [Azotobacter chroococcum]
MYDYPITVHSEAGHYWSSCPDIPEAHSAGDTIGMLLANAFDGIRLALTIYVDQGRSIPPASPAKAGQYVVSLPAQTVAKV
HLWNTMREQGLRVADLARLLGVSHPVATRLVDFEHVSKIEQIERALHALGKRLSVSVEAA

Download         Length: 423 bp

>AT184281 NZ_CP087593:2274808-2274846 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References