Detailed information of TA system TA184279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1515626..1516141
• Replicon: chromosome
• Accession: NZ_CP066310
• Organism: Azotobacter chroococcum strain HR1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0C4WII4
• Locus tag: GKQ51_RS07065
• Protein ID: WP_039805097.1
• Coordinates: 1515887..1516141 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GKQ51_RS07060
• Protein ID: WP_198867542.1
• Coordinates: 1515626..1515883 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ51_RS07045	1511922..1513457	-	1536	WP_198867540.1	Tar ligand binding domain-containing protein	-
GKQ51_RS07050	1513751..1514164	+	414	WP_198867541.1	MarR family winged helix-turn-helix transcriptional regulator	-
GKQ51_RS07055	1514217..1515413	+	1197	WP_198868021.1	MFS transporter	-
GKQ51_RS07060	1515626..1515883	+	258	WP_198867542.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GKQ51_RS07065	1515887..1516141	+	255	WP_039805097.1	Txe/YoeB family addiction module toxin	Toxin
GKQ51_RS07070	1516135..1516512	-	378	WP_198867543.1	hypothetical protein	-
GKQ51_RS07075	1516660..1517388	+	729	WP_089167648.1	SIMPL domain-containing protein	-
GKQ51_RS07080	1517436..1518668	-	1233	WP_136888625.1	MFS transporter	-
GKQ51_RS07085	1519181..1520197	-	1017	WP_039805088.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9990.42 Da
• Isoelectric Point: 8.0486

>T184279 WP_039805097.1 NZ_CP066310:1515887-1516141 [Azotobacter chroococcum]
MNILFTPEAWDDYLWFQQNDKAGLKRINLLIRDAQRDPFGGLGKPEPLKHNLSGFWSRRIGEEHRLVYRVDGDALQIVMC
RYHY

Nucleotide

• Length: 255 bp

>T184279 NZ_CP087593:c2198104-2197742 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9512.80 Da
• Isoelectric Point: 7.0109

>AT184279 WP_198867542.1 NZ_CP066310:1515626-1515883 [Azotobacter chroococcum]
MQTINYTTARQHLAETMDRVNNDRTPILVTRQKGEPVVMISLADYNALEETAYLLRSPANAERLIRSIASLRAGKAEPRS
LVDEG

Nucleotide

• Length: 258 bp

>AT184279 NZ_CP087593:c2198271-2198101 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C4WII4