Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 471248..471901 Replicon chromosome
Accession NZ_CP066308
Organism Brevibacillus sp. FJAT-54423

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JD108_RS02540 Protein ID WP_198828445.1
Coordinates 471551..471901 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JD108_RS02535 Protein ID WP_198828444.1
Coordinates 471248..471547 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JD108_RS02500 466288..466623 + 336 WP_198828437.1 metalloregulator ArsR/SmtB family transcription factor -
JD108_RS02505 466647..466898 - 252 WP_198828438.1 glutaredoxin family protein -
JD108_RS02510 467097..467267 + 171 WP_198828439.1 gamma-type small acid-soluble spore protein -
JD108_RS02515 467385..467783 + 399 WP_198828440.1 holo-ACP synthase -
JD108_RS02520 468042..469076 + 1035 WP_198828441.1 DUF4367 domain-containing protein -
JD108_RS02525 469440..469880 + 441 WP_198828442.1 hypothetical protein -
JD108_RS02530 469884..471086 + 1203 WP_198828443.1 alanine racemase -
JD108_RS02535 471248..471547 + 300 WP_198828444.1 CopG family ribbon-helix-helix protein Antitoxin
JD108_RS02540 471551..471901 + 351 WP_198828445.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JD108_RS02545 472099..472521 + 423 WP_198828446.1 anti-sigma regulatory factor -
JD108_RS02550 472530..473549 + 1020 WP_198828447.1 PP2C family protein-serine/threonine phosphatase -
JD108_RS02555 473551..473877 + 327 WP_198828448.1 STAS domain-containing protein -
JD108_RS02560 473877..474365 + 489 WP_198828449.1 anti-sigma B factor RsbW -
JD108_RS02565 474334..475122 + 789 WP_198828450.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-52)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12961.98 Da        Isoelectric Point: 4.8553

>T184277 WP_198828445.1 NZ_CP066308:471551-471901 [Brevibacillus sp. FJAT-54423]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKMYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMERVNESLQISLGIIDF

Download         Length: 351 bp

>T184277 NZ_CP087593:c2099232-2099056 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11288.17 Da        Isoelectric Point: 10.2102

>AT184277 WP_198828444.1 NZ_CP066308:471248-471547 [Brevibacillus sp. FJAT-54423]
MVGGGFVLSKSNTKRIMISLPHHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRAIRETMQKGYMEMAKINLNMASE
AFGAEEEADHTLVRLVSGV

Download         Length: 300 bp

>AT184277 NZ_CP087593:2098933-2098988 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References