Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1655678..1656187 Replicon chromosome
Accession NZ_CP066303
Organism Staphylococcus epidermidis strain SE48

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag JCQ37_RS07930 Protein ID WP_001829980.1
Coordinates 1655678..1655887 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag JCQ37_RS07935 Protein ID WP_001829893.1
Coordinates 1655894..1656187 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCQ37_RS07910 1651257..1652612 - 1356 WP_002485725.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JCQ37_RS07915 1652624..1653697 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
JCQ37_RS07920 1654088..1655299 + 1212 WP_002485731.1 rod shape-determining protein RodA -
JCQ37_RS07925 1655398..1655535 - 138 WP_001829949.1 hypothetical protein -
JCQ37_RS07930 1655678..1655887 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
JCQ37_RS07935 1655894..1656187 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
JCQ37_RS07940 1656361..1657845 + 1485 WP_002457116.1 cardiolipin synthase -
JCQ37_RS07945 1658027..1658680 + 654 WP_001829983.1 HD domain-containing protein -
JCQ37_RS07950 1658786..1659658 - 873 WP_002458703.1 membrane protein insertase YidC -
JCQ37_RS07955 1659747..1660385 - 639 WP_002505076.1 thiamine phosphate synthase -
JCQ37_RS07960 1660391..1661179 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T184271 WP_001829980.1 NZ_CP066303:c1655887-1655678 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T184271 NZ_CP087590:c1865422-1865156 [Vibrio sp. VB16]
ATGAGTAACCAACGCTTGTTGTCGTGGACTGATGAGGCTTGGGGTAGTTACCTTTACTGGCAGACTCAAGACAAAAAGAC
GTTGAAGCGCATAAATAAACTTATCAATGATGTGAAGCGAACGCCATTTGAAGGTATTGGTAAACCCGAGCCATTGAAAG
AAAATTTATCAGGATTCTGGTCTCGCCGTATAGATGATACTAACCGTTTAGTTTATGCAGTGGATGGGGAAACAATGACC
ATAATTTCTTGTCGTTATCACTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT184271 WP_001829893.1 NZ_CP066303:c1656187-1655894 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT184271 NZ_CP087590:c1865669-1865415 [Vibrio sp. VB16]
ATGAGAATAGTATCTTTTACGGAAGCAAGAAACGGACTAAAAGCTGTTTTAGATAGTGTCGTGAATGACGCAGATACAAC
AGTTATTACCCGTCGTGACTCTGAAGATGCTGTGGTAATGTCTTTAGACTATTACAATAGCTTGATGGAAACGGTTCATT
TGCTTCGATCTCCCAAAAACGCAGAACACCTAAACCGTTCAATAGCGCAATACCGTGCAGGTAAAGTAGAAGCACGAGAA
CTAATAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References