Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1644473..1645002 Replicon chromosome
Accession NZ_CP066303
Organism Staphylococcus epidermidis strain SE48

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag JCQ37_RS07870 Protein ID WP_001829891.1
Coordinates 1644473..1644835 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag JCQ37_RS07875 Protein ID WP_001829931.1
Coordinates 1644832..1645002 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCQ37_RS07850 1641475..1642245 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
JCQ37_RS07855 1642220..1642699 - 480 WP_001829903.1 anti-sigma B factor RsbW -
JCQ37_RS07860 1642701..1643027 - 327 WP_001829952.1 anti-sigma factor antagonist -
JCQ37_RS07865 1643127..1644128 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
JCQ37_RS07870 1644473..1644835 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JCQ37_RS07875 1644832..1645002 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JCQ37_RS07880 1645089..1646237 - 1149 WP_002457107.1 alanine racemase -
JCQ37_RS07885 1646304..1646657 - 354 WP_002457108.1 holo-ACP synthase -
JCQ37_RS07890 1646705..1647214 - 510 WP_002485728.1 PH domain-containing protein -
JCQ37_RS07895 1647201..1648706 - 1506 WP_002485729.1 PH domain-containing protein -
JCQ37_RS07900 1648699..1649178 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T184270 WP_001829891.1 NZ_CP066303:c1644835-1644473 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T184270 NZ_CP087590:c698154-696853 [Vibrio sp. VB16]
ATGCAAAAGCTAATAGCATACATGAATGGTGAACTTGTTGGTGCTTTGGAGAAACGTAAGAATGGAGCCCATACTTTTCA
ATATGATAAGAGCTGGGTAAATAACGTTAAGACTCGCCCATTATCATTATCTTTAAAGCTTCAATTGCCCCCAATAACTT
CAGATGCCGTTATAAACTATTTTGATAACCTCTTGCCAGATAGCCCACAGGTCAGAGATAGGATCGTTTCTAGGTACAAA
ACTTCATCCAAACAACCCTTCGACCTCCTTAAAGAAGTTGGTAAGGATAGCGTAGGTGCAATTACATTGCTTCCACCCGA
GCTTCCCTACAAAAAAGAACCACTCAACTATGAAGTATTGGATGATAAGAAGCTAGAAGCCGTGCTCTCTGGATATAAGT
CAGATATTCCACTCGGGATGCTTGAAGAAGAAGAAGACTTTAGAATATCGGTAGCAGGTGCTCAAGAGAAAACTGCGCTC
CTGTTCGTAGACGGACAATGGTGTATACCGAAAGGAAACACGCCAACAACCCATATTATCAAACTGCCAATTGGTGAGAT
ACAACAGGCCAATGCAACACTGGATCTCAAAGACAGTGTAGAGAACGAATACCTTTGCATTGAGCTAGCCAGAGCTCTGG
GGTTTATAGTTCCCAACGTTAGTATAATCGAAACAGATAGCCTTAAAGCTCTAGCAGTAGAACGATTTGACCGACGCTGG
ACGAAAGACAAGTCAGGTTTGATTCGCCTTCCTCAAGAAGATATTTGCCAGGTGTTTGGCATGCCATCATCAATCAAATA
CGAATCTCAGGGTGGCCCTAGCATCGCCCAGATCATGGCGTTACTAATGGGCTCAAGCAATGCCCTAGAAGATCGGTATA
ACTTCATGAGATTCCAAGTGTTTCAATGGATTATAGGCGCTACAGACGGACACGCTAAAAACTTCTCTATCTACATTGAT
AAAGGTGGTAGCTATAGCCTAACTCCGTTCTACGATATTTTATCAGCTTACCCACTCTTAGGGGGCAAAGGGCTCAATAT
TAGAAAGTTAAAACTAGCTATGGGACTAAAAGCGACGAAAGGCAAAAAGTATGAGGTGAATAAAATCTTACCTCGTCACT
TTTTAGATACGGCGAAAGCTGTAAACTTTAATCAAGACAAGATGCAAAAGATAATGGATGAAATGAAAGATGCGCTACCT
AAAGCGATCTTACAAGTAAAAGCTAATCTACCAAAGGATTTTCCTGAACACATCTCAGACTCAATTTTTGAGAATGCTAA
GAAAATAATTAAGAAAATTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT184270 WP_001829931.1 NZ_CP066303:c1645002-1644832 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT184270 NZ_CP087590:c698399-698154 [Vibrio sp. VB16]
ATGATATATAGTCCAAAACAGCTAGCAGACATGATGCTCCTGATACGCCAAAAGAACGGCTGGACTCAATCAGAGCTGGC
GAAAAAGGTTGGTATAAAGCAAGCAACCATCTCAAACTTTGAGAACAACCCCAACAAAACAACACTTTCGACCTTCTTTA
AGCTTATTCAAGCAATGGATCTGACACTTAGCATTCAAGAAAAAACTCTGGTGGCTTCGCTAGATGAAAATGATGAGAGT
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References