Detailed information of TA system TA184269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1485267..1486069
• Replicon: chromosome
• Accession: NZ_CP066303
• Organism: Staphylococcus epidermidis strain SE48

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: JCQ37_RS06965
• Protein ID: WP_002468490.1
• Coordinates: 1485267..1485446 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: JCQ37_RS06970
• Protein ID: WP_002485603.1
• Coordinates: 1485470..1486069 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCQ37_RS06945	1480660..1481793	-	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-
JCQ37_RS06950	1481952..1482776	+	825	WP_002468488.1	RluA family pseudouridine synthase	-
JCQ37_RS06955	1483137..1484522	-	1386	WP_001829862.1	class II fumarate hydratase	-
JCQ37_RS06960	1484707..1485111	-	405	WP_002485605.1	hypothetical protein	-
JCQ37_RS06965	1485267..1485446	-	180	WP_002468490.1	hypothetical protein	Toxin
JCQ37_RS06970	1485470..1486069	-	600	WP_002485603.1	glucosamine-6-phosphate isomerase	Antitoxin
JCQ37_RS06975	1486227..1486697	-	471	WP_001829836.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JCQ37_RS06980	1486694..1487824	-	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
JCQ37_RS06985	1488039..1488188	-	150	WP_002468809.1	hypothetical protein	-
JCQ37_RS06990	1488685..1489407	-	723	WP_001829838.1	amino acid ABC transporter ATP-binding protein	-
JCQ37_RS06995	1489400..1490857	-	1458	WP_002440300.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T184269 WP_002468490.1 NZ_CP066303:c1485446-1485267 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T184269 NZ_CP087590:229088-229372 [Vibrio sp. VB16]
ATGAAATTAAAGTGGGAACATCAATCTCTAGATGACCGCTATGATATTTTTGAATATTTATATGAATTTAACGCTTTAGC
CGCTGAAAAAACAGACGCTACTATAGTGAATAGAGCGATGTTGTTGTTAGAACACCTACTCATGGGGATAGAAAGAGAAG
ATAGGAGAGGGCGCTACCTAATTATTCCAGAAATTTCAATGCTACTATCTTATGAGTTCGATGGTGATTTAATTAGAATC
CATCGAGTTATCCATACCAAGAAGATGTTCCCAGAGAAATCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22677.52 Da
• Isoelectric Point: 4.8641

>AT184269 WP_002485603.1 NZ_CP066303:c1486069-1485470 [Staphylococcus epidermidis]
MAINFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT184269 NZ_CP087590:228804-229085 [Vibrio sp. VB16]
ATGGAAACCAGAGTTCAATTCAGAATAGATGAACAAACAAAGTCATTAGCGCAAAAAGCAATTGAAAGAAAAGGTGGAAC
ACTAAGTGACGCTTGTCGAAAATTAGCAGAAGACTTGGCTCAAGAGCAGCGTCAGTTTGAAAACCATGATTCATGGCTTA
CCGATCAAATTAACACGGCGTTTGATAAGTACGACCAGGGAGAAGCCAAATTCTTTTCTCACGATGAAGCCGAAAGAATA
ATGGAAGATAGAAAAAATAAGATTAGAAATAAGGCAATATAG

Structures

Toxin

• AlphaFold DB: A0A2G7HY44