Detailed information of TA system TA184268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1720416..1720987
• Replicon: chromosome
• Accession: NZ_CP066294
• Organism: Streptococcus mutans strain 27-3

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IGS65_RS08495
• Protein ID: WP_192072029.1
• Coordinates: 1720655..1720987 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A2J9QC51
• Locus tag: IGS65_RS08490
• Protein ID: WP_002264866.1
• Coordinates: 1720416..1720661 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGS65_RS08455	1715917..1716663	+	747	WP_192072028.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
IGS65_RS08460	1716687..1717547	+	861	WP_002262997.1	DegV family protein	-
IGS65_RS08465	1717679..1718194	+	516	WP_002294743.1	hypothetical protein	-
IGS65_RS08470	1718194..1718640	+	447	WP_002301188.1	hypothetical protein	-
IGS65_RS08475	1718637..1718831	+	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
IGS65_RS08480	1719231..1719677	+	447	WP_002262993.1	50S ribosomal protein L13	-
IGS65_RS08485	1719702..1720094	+	393	WP_002262992.1	30S ribosomal protein S9	-
IGS65_RS08490	1720416..1720661	+	246	WP_002264866.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
IGS65_RS08495	1720655..1720987	+	333	WP_192072029.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IGS65_RS08500	1721185..1721976	-	792	WP_088723867.1	DUF4037 domain-containing protein	-
IGS65_RS08505	1722292..1724052	+	1761	WP_192072030.1	PDZ domain-containing protein	-
IGS65_RS08510	1724054..1724671	+	618	WP_002270664.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-107)

Antitoxin

• Antitoxin PemI-like (1-81)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12648.60 Da
• Isoelectric Point: 7.1612

>T184268 WP_192072029.1 NZ_CP066294:1720655-1720987 [Streptococcus mutans]
MVTIKQGSIIKINLVPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Nucleotide

• Length: 333 bp

>T184268 NZ_CP087587:925978-927249 [Croceicoccus sp. Ery5]
GTGACGCTGCCAATTCTGGATACGCTTATGGTCTGGTGGGACAAGCGCAAGGCAGGCGAACTCTGGATCGACAAAGGTGG
CGCGATGCATTTCGCATATACGCCTGAATGGCTGGCTGATGAAACTGCCCCGGCGCTTTCCCATGCGATGCCTAAGAAGC
AAGAGTCGTTTAAGGACCATGCGTGCAAGGCCGTTTTTGGTGGGCTGCTTCCCGAAGAAAGCCAGCGCACCGCTATCGCT
CGGGCACTTGGAGTTTCGCCCGACAATCCTTTTCGCCTGCTTGAGGCCTTGGGCGGAGATGTTGCCGGTGCTCTAGCCTT
CCTGCCCAAACACGAAGAACCGCTCCAGGACTGCTCCGAGACCACTCCAGAACCACTCCAAGAGGGCGAGCTAGCGAAAC
TGCTCGATCGGTTGCCAGCTGTGCCCATGCTGGCAGGCGAGGGCGGCGCGAGGCTCAGCCTTGCAGGCGCACAGAGCAAA
CTGCCAGTGCTGGTCACTGCGGACGGTGGCATTGCGATCCCTCGCCTTGGAGAACCATCCACGCACCTGATCAAGCCTGA
ACCGGATCGCTTTGCCGGATTAGCTGCGAATGAGGCCTTCTGCCTCGCACTGGCGCGCGCGGCGGGCATTGATGCTGCCA
CTGCAGAGTGGCGCGAGGTGGCTGGGAAGCCGTTGCTGCTGGTCGAACGCTATGACCGGATGTCGGTCGAGGGAAAAACG
AAACGCTTGCATCAGGAAGACTTCGCTCAGGCACTAAGCGTCCCCTCAAACCGCAAATACGCGGCGGAGGGCGGGCCGAC
TTTCCGCGATAGCTTCGCGCTGTTGCGCAGCGCTGCGACGCGGCCAGCGCGCGAAGTGCTGAAGCTCGCCGACGCGGCGA
TCTTCAATCTCATCATCGGCAACGCCGATGCCCACGCTAAGAACTACAGTCTGCTGCGCCGGGAAAACGGCGAGGTGGTG
CTTGCCCCGCTCTACGATCTTGTCGCCACGCATATGTGGAAGGAGCTCTCCCCCAAGCTCGCAATGAGATTTGGTAACGC
GGCGACCCTCGAAGAATTTGACAGCAAATGCGTGGCGAGGTTCGCGGACGAAGCAGGGCTAGGTGCTCCGTACATTCGCC
GCAGGGTGAGTGACCTTGCTGACGCAGTGACGGAGGAAATTGAGAAGGGCGTTCAGGTGCCCGGCAATCCGCCTGAGGAT
GCTGTCGCGCCAATTGCCGAAGCATTATCGACCCGCGCCAGCGCTGCTGCACTGAAGCTTTTGGAAGCGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9255.55 Da
• Isoelectric Point: 4.3021

>AT184268 WP_002264866.1 NZ_CP066294:1720416-1720661 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Nucleotide

• Length: 246 bp

>AT184268 NZ_CP087587:925724-925981 [Croceicoccus sp. Ery5]
ATGCTCAATGTTGCCACTATTGGCCAAATCATTCGCGATGAACGCAAGGAGCTTGGTCTGCGACAGGACGAGTTGGCTGC
TGCAAGCGGCGTCGGCTTGCGCTTCCTCGTTGAACTGGAGCGAGGGAAGGTAACCGTCCAGATGGGCAAAGTGCTCGATG
TTCTCGCCGCACTTGGTTGTGAATTGCAAATCAAGCGGCCTGACGGGATCGTGATAGCGGGTCGAGCGGTCGCGCCCAAG
AAGGATGAGGCGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2J9QC51