184267

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) SmuAT/-
Location 1717679..1718640 Replicon chromosome
Accession NZ_CP066294
Organism Streptococcus mutans strain 27-3

Toxin (Protein)


Gene name smuT Uniprot ID -
Locus tag IGS65_RS08465 Protein ID WP_002294743.1
Coordinates 1717679..1718194 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name smuA Uniprot ID -
Locus tag IGS65_RS08470 Protein ID WP_002301188.1
Coordinates 1718194..1718640 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS65_RS08440 1713096..1713833 + 738 WP_002263001.1 MerR family transcriptional regulator -
IGS65_RS08445 1713869..1714861 - 993 WP_192072027.1 BtrH N-terminal domain-containing protein -
IGS65_RS08450 1715050..1715604 - 555 WP_002262999.1 PadR family transcriptional regulator -
IGS65_RS08455 1715917..1716663 + 747 WP_192072028.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
IGS65_RS08460 1716687..1717547 + 861 WP_002262997.1 DegV family protein -
IGS65_RS08465 1717679..1718194 + 516 WP_002294743.1 hypothetical protein Toxin
IGS65_RS08470 1718194..1718640 + 447 WP_002301188.1 hypothetical protein Antitoxin
IGS65_RS08475 1718637..1718831 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
IGS65_RS08480 1719231..1719677 + 447 WP_002262993.1 50S ribosomal protein L13 -
IGS65_RS08485 1719702..1720094 + 393 WP_002262992.1 30S ribosomal protein S9 -
IGS65_RS08490 1720416..1720661 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
IGS65_RS08495 1720655..1720987 + 333 WP_192072029.1 type II toxin-antitoxin system PemK/MazF family toxin -
IGS65_RS08500 1721185..1721976 - 792 WP_088723867.1 DUF4037 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(4-200)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19548.19 Da        Isoelectric Point: 9.8654

>T184267 WP_002294743.1 NZ_CP066294:1717679-1718194 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCHSILNDAYFTARKNKKFLYVYAVIIAVQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Download         Length: 516 bp

>T184267 NZ_CP087584:c4441666-4440953 [Providencia rettgeri]
GTGACTTTATTCGCTCAAGTACTGGGGCTCATCAGTTTAAATGATGTGCCCCATAGTTTTATTTTAAATGTAGGTGAAAT
AAAGGCGTTAGCGGTTGAACGTTTTGATCGTAAATATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATT
TTTGTCAAACATTGAATATTTCACCAGCAAGAAAATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTAC
TTATTAGGTTCAATAAATGCAGAGAAAGATAGATATCAGTTTATGAAGAGCCAGGTTTTGTTTTGGTTACTTGCAGCGAC
GGATGGCCATGCTAAAAATTTTTCATTATTTATTGAACCTGAAGGCTGTTATCAGTTAACACCTTTTTACGATATTTTGT
CCATGTATCCTAGTTATGGGGGGAGGGGAATTAACCCTAGAGATGCCAAATTGGCTATGGGGCTAAAGGGAACAAGGGAG
ATGAAATACAATATAGAGCAAATTTTTCCAAGGCATTTTTTTGCAACGGCCAAGGAGGTTGGTTTTGACCGCACTGAAAT
GGAAAAAATCTTAATTGAGTTTGATGAGCAAATGGAAAGTGTTATTACAAAGGTTAGGGAACAGCTTCCAACCAATTTCC
CTAAGCACATTGCAGACTCAATTTTATCAGGGTTACATCATAAAGCCGCACGATTAAAAAAAGGTTGGGATTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16982.26 Da        Isoelectric Point: 9.5767

>AT184267 WP_002301188.1 NZ_CP066294:1718194-1718640 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKADLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIIYRHYLDKKEADK

Download         Length: 447 bp

>AT184267 NZ_CP087584:c4441969-4441706 [Providencia rettgeri]
ATGAAAGTGACCAATACCCGACAACTTAGTGCTTACATGAAAGATGTCAGAGAGACGAAAAAATTATCTCAAAGTAAAGT
CGCAAGTAAAGTGGGTATTCGGCAAGATACCGTCTCCAGTTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTCT
TTAAGATTTTATCTGCCCTAAATTTAGAACTCGATATTAAACCGCGAAATGAAAGTGGCTCATCAAACTCAAATTCAAAC
TCTGGATGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References