Detailed information of TA system TA184266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 409484..410154
• Replicon: plasmid unnamed1
• Accession: NZ_CP066273
• Organism: Agrobacterium tumefaciens strain FDAARGOS_1048

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6I05_RS01920
• Protein ID: WP_003517201.1
• Coordinates: 409735..410154 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7U5CZ71
• Locus tag: I6I05_RS01915
• Protein ID: WP_038496682.1
• Coordinates: 409484..409738 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I05_RS01905	407235..408454	+	1220	WP_121556223.1	IS3 family transposase	-
I6I05_RS01910	408511..409116	-	606	WP_035201472.1	J domain-containing protein	-
I6I05_RS01915	409484..409738	+	255	WP_038496682.1	plasmid stabilization protein	Antitoxin
I6I05_RS01920	409735..410154	+	420	WP_003517201.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6I05_RS01925	410381..411277	-	897	WP_038496685.1	dihydrodipicolinate synthase family protein	-
I6I05_RS01930	411310..412191	-	882	WP_038496688.1	SMP-30/gluconolactonase/LRE family protein	-
I6I05_RS01935	412248..412967	-	720	WP_038496691.1	FadR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..815865	815865

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (1-66)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 17962.39 Da
• Isoelectric Point: 12.9430

>T184266 WP_003517201.1 NZ_CP066273:409735-410154 [Agrobacterium tumefaciens]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 420 bp

>T184266 NZ_CP087584:2893850-2894158 [Providencia rettgeri]
ATGCAATATTGCCTCTATCAAAATCGAGAAAATACAGTCAAACACCCATATTTACTGGACATTCAAAGTAATATTATTGA
TATATTGAATACTCTTTTAGTCATCCCGTTATTCGATAGCAGGCTAGTTAAAAAGCCATTACCTACTTGCCTTAACCCCC
AGTTATTTAGCAACGGGCAGGTGTTTGTTTTAATGACACACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTGAACTGCCAACATAACACGATTAAACACGCAATTGACTTACTTATTGATGGCTTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10912.81 Da
• Isoelectric Point: 12.7242

>AT184266 WP_038496682.1 NZ_CP066273:409484-409738 [Agrobacterium tumefaciens]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKK

Nucleotide

• Length: 255 bp

>AT184266 NZ_CP087584:2893650-2893850 [Providencia rettgeri]
ATCACTGTAGCGCCTGAGCTCTGCGAACAAGCAAGGCGGGCTAAACTCAACTTATCTGCAATACTAACTTGTGCCTTACA
AGCTGAATTAAAACGCCTAGAAGCACAAAAGTGGAAAAATGAAAATATCGAAGGTTTTAATCAATTAAATAGGATCAATG
AAGAATACGGATTACTCTCAGATAAATACAAGGGTTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U5CZ71