Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 89658..90205 Replicon plasmid p1
Accession NZ_CP066271
Organism Pseudomonas tremae strain PA-1-10F

Toxin (Protein)


Gene name relE Uniprot ID A0A3M4CHK7
Locus tag I9H09_RS26405 Protein ID WP_060413327.1
Coordinates 89930..90205 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H1ZWV1
Locus tag I9H09_RS26400 Protein ID WP_015060662.1
Coordinates 89658..89930 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9H09_RS26380 (I9H09_26255) 84835..85140 + 306 WP_122346904.1 conjugal transfer protein -
I9H09_RS26385 (I9H09_26260) 85191..88157 - 2967 WP_236502509.1 Tn3 family transposase -
I9H09_RS26390 (I9H09_26265) 88161..88721 - 561 WP_122346646.1 recombinase family protein -
I9H09_RS26395 (I9H09_26270) 88817..89440 - 624 WP_122346645.1 hypothetical protein -
I9H09_RS26400 (I9H09_26275) 89658..89930 + 273 WP_015060662.1 ribbon-helix-helix domain-containing protein Antitoxin
I9H09_RS26405 (I9H09_26280) 89930..90205 + 276 WP_060413327.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I9H09_RS26410 (I9H09_26285) 90595..91110 + 516 WP_236502508.1 StbB family protein -
I9H09_RS26415 91118..91345 + 228 WP_248972613.1 hypothetical protein -
I9H09_RS26420 (I9H09_26290) 91342..91914 + 573 WP_122347984.1 hypothetical protein -
I9H09_RS26425 (I9H09_26295) 91941..92480 - 540 WP_054990103.1 hypothetical protein -
I9H09_RS26430 (I9H09_26300) 92700..93425 + 726 WP_236502506.1 relaxosome protein -
I9H09_RS26435 93415..94071 + 657 Protein_97 relaxase/mobilization nuclease domain-containing protein -
I9H09_RS26440 94412..94831 + 420 WP_054990105.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..98897 98897


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10753.26 Da        Isoelectric Point: 7.0128

>T184262 WP_060413327.1 NZ_CP066271:89930-90205 [Pseudomonas tremae]
MELKWTSKALSDITRLYEFLASVNQPAAARAVQQLTTAPTTLLTNPRIGERLEEFEPRDVRRIQIGQYEMRYEIADSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T184262 NZ_CP087581:26004-26420 [Klebsiella quasipneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10076.40 Da        Isoelectric Point: 5.6994

>AT184262 WP_015060662.1 NZ_CP066271:89658-89930 [Pseudomonas tremae]
MATTAKTRSVTAHVPVQLAEKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT184262 NZ_CP087581:25777-26007 [Klebsiella quasipneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAAGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M4CHK7

Antitoxin

Source ID Structure
AlphaFold DB A0A3M4CJB9

References