Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4844051..4844567 Replicon chromosome
Accession NZ_CP066254
Organism Klebsiella pneumoniae strain CRKP78R

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JCR35_RS23925 Protein ID WP_002886902.1
Coordinates 4844051..4844335 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JCR35_RS23930 Protein ID WP_002886901.1
Coordinates 4844325..4844567 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCR35_RS23900 4839535..4839843 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JCR35_RS23905 4839928..4840101 + 174 WP_002886906.1 hypothetical protein -
JCR35_RS23910 4840104..4840847 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JCR35_RS23915 4841204..4843342 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JCR35_RS23920 4843583..4844047 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JCR35_RS23925 4844051..4844335 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JCR35_RS23930 4844325..4844567 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JCR35_RS23935 4844645..4846555 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JCR35_RS23940 4846578..4847732 - 1155 WP_002886900.1 lactonase family protein -
JCR35_RS23945 4847798..4848538 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T184241 WP_002886902.1 NZ_CP066254:c4844335-4844051 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T184241 NZ_CP087578:c2095347-2095240 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCGCGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT184241 WP_002886901.1 NZ_CP066254:c4844567-4844325 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT184241 NZ_CP087578:2095394-2095460 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References