Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4127006..4127625 Replicon chromosome
Accession NZ_CP066254
Organism Klebsiella pneumoniae strain CRKP78R

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JCR35_RS20490 Protein ID WP_002892050.1
Coordinates 4127407..4127625 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JCR35_RS20485 Protein ID WP_002892066.1
Coordinates 4127006..4127380 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCR35_RS20475 4122158..4123351 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JCR35_RS20480 4123374..4126520 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
JCR35_RS20485 4127006..4127380 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JCR35_RS20490 4127407..4127625 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JCR35_RS20495 4127784..4128350 + 567 WP_002892030.1 maltose O-acetyltransferase -
JCR35_RS20500 4128322..4128462 - 141 WP_004147370.1 hypothetical protein -
JCR35_RS20505 4128483..4128953 + 471 WP_002892026.1 YlaC family protein -
JCR35_RS20510 4128928..4130379 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JCR35_RS20515 4130480..4131178 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
JCR35_RS20520 4131175..4131315 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JCR35_RS20525 4131315..4131578 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184239 WP_002892050.1 NZ_CP066254:4127407-4127625 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T184239 NZ_CP087578:c2094276-2094169 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT184239 WP_002892066.1 NZ_CP066254:4127006-4127380 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT184239 NZ_CP087578:2094326-2094389 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References