Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4908092..4908608 Replicon chromosome
Accession NZ_CP066249
Organism Klebsiella pneumoniae strain CRKP52R

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JCR34_RS24280 Protein ID WP_002886902.1
Coordinates 4908092..4908376 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JCR34_RS24285 Protein ID WP_002886901.1
Coordinates 4908366..4908608 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCR34_RS24255 4903576..4903884 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JCR34_RS24260 4903969..4904142 + 174 WP_002886906.1 hypothetical protein -
JCR34_RS24265 4904145..4904888 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JCR34_RS24270 4905245..4907383 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JCR34_RS24275 4907624..4908088 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JCR34_RS24280 4908092..4908376 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JCR34_RS24285 4908366..4908608 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JCR34_RS24290 4908686..4910596 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JCR34_RS24295 4910619..4911773 - 1155 WP_002886900.1 lactonase family protein -
JCR34_RS24300 4911839..4912579 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T184212 WP_002886902.1 NZ_CP066249:c4908376-4908092 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T184212 NZ_CP087570:2146137-2146433 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT184212 WP_002886901.1 NZ_CP066249:c4908608-4908366 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT184212 NZ_CP087570:2146435-2146830 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References