Detailed information of TA system TA184196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2000300..2000847
• Replicon: chromosome
• Accession: NZ_CP066246
• Organism: Vibrio parahaemolyticus strain DHO76

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2A9G0H4
• Locus tag: H9K57_RS09680
• Protein ID: WP_025523589.1
• Coordinates: 2000300..2000602 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H9K57_RS09685
• Protein ID: WP_140192124.1
• Coordinates: 2000590..2000847 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9K57_RS09620 (H9K57_09510)	1995310..1995402	-	93	WP_080258667.1	DUF3265 domain-containing protein	-
H9K57_RS09625 (H9K57_09515)	1995440..1995802	-	363	WP_029841645.1	hypothetical protein	-
H9K57_RS09630 (H9K57_09520)	1995933..1996337	-	405	WP_140128075.1	DUF1801 domain-containing protein	-
H9K57_RS09635 (H9K57_09525)	1996474..1997265	-	792	WP_031850381.1	DUF3800 domain-containing protein	-
H9K57_RS09640 (H9K57_09530)	1997310..1997399	-	90	WP_193289419.1	DUF3265 domain-containing protein	-
H9K57_RS09645 (H9K57_09535)	1997435..1997737	-	303	WP_038892258.1	hypothetical protein	-
H9K57_RS09650 (H9K57_09540)	1997878..1998219	-	342	WP_248377288.1	SH3 domain-containing protein	-
H9K57_RS09655 (H9K57_09545)	1998247..1998339	-	93	WP_077345978.1	DUF3265 domain-containing protein	-
H9K57_RS09660 (H9K57_09550)	1998361..1998849	-	489	WP_029865851.1	hypothetical protein	-
H9K57_RS09665 (H9K57_09555)	1999008..1999277	-	270	WP_021707508.1	hypothetical protein	-
H9K57_RS09670 (H9K57_09560)	1999425..2000144	-	720	WP_248377289.1	hypothetical protein	-
H9K57_RS09675 (H9K57_09565)	2000202..2000303	-	102	Protein_1887	DUF3265 domain-containing protein	-
H9K57_RS09680 (H9K57_09570)	2000300..2000602	-	303	WP_025523589.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9K57_RS09685 (H9K57_09575)	2000590..2000847	-	258	WP_140192124.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9K57_RS09690 (H9K57_09580)	2000929..2001021	-	93	WP_079879139.1	DUF3265 domain-containing protein	-
H9K57_RS09695 (H9K57_09585)	2001054..2001299	-	246	WP_017449587.1	hypothetical protein	-
H9K57_RS09700 (H9K57_09590)	2001515..2002138	-	624	WP_248377290.1	hypothetical protein	-
H9K57_RS09705 (H9K57_09595)	2002166..2002258	-	93	WP_193784373.1	DUF3265 domain-containing protein	-
H9K57_RS09710 (H9K57_09600)	2002283..2002870	-	588	WP_225471077.1	hypothetical protein	-
H9K57_RS09715 (H9K57_09605)	2002899..2002988	-	90	WP_248378005.1	DUF3265 domain-containing protein	-
H9K57_RS09720 (H9K57_09610)	2003006..2003482	-	477	WP_248377287.1	GNAT family N-acetyltransferase	-
H9K57_RS09725 (H9K57_09615)	2003516..2003608	-	93	WP_193837464.1	DUF3265 domain-containing protein	-
H9K57_RS09730 (H9K57_09620)	2003758..2004243	+	486	WP_017633497.1	hypothetical protein	-
H9K57_RS09735 (H9K57_09625)	2004417..2004863	-	447	WP_109169664.1	GNAT family N-acetyltransferase	-
H9K57_RS09740 (H9K57_09630)	2005020..2005415	-	396	WP_140310356.1	ACT domain-containing protein	-
H9K57_RS09745 (H9K57_09635)	2005448..2005540	-	93	WP_078581101.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1940332..2020584	80252
	-	inside	Integron	-	-	1946709..2019459	72750

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11656.53 Da
• Isoelectric Point: 4.8951

>T184196 WP_025523589.1 NZ_CP066246:c2000602-2000300 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTIFSKVERLESFPESGRIPPELEHLSYREVVVNPCRVFYKQDADKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T184196 NZ_CP087564:3693639-3693812 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9627.11 Da
• Isoelectric Point: 7.2032

>AT184196 WP_140192124.1 NZ_CP066246:c2000847-2000590 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLRDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLSILEGIARGERALADGKAVSHEEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT184196 NZ_CP087564:3693315-3693611 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A2A9G0H4