Detailed information of TA system TA184193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1290304..1290983
• Replicon: chromosome
• Accession: NZ_CP066237
• Organism: Acinetobacter baumannii strain G20AB007

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: JCR16_RS06330
• Protein ID: WP_000838146.1
• Coordinates: 1290304..1290486 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: JCR16_RS06335
• Protein ID: WP_000966688.1
• Coordinates: 1290579..1290983 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR16_RS06290	1285418..1285822	+	405	WP_000247948.1	hypothetical protein	-
JCR16_RS06295	1285794..1286162	+	369	WP_002055488.1	hypothetical protein	-
JCR16_RS06300	1286164..1286562	+	399	WP_001251850.1	hypothetical protein	-
JCR16_RS06305	1286564..1286782	+	219	WP_070423369.1	hypothetical protein	-
JCR16_RS06310	1286878..1287231	+	354	WP_015451444.1	hypothetical protein	-
JCR16_RS06315	1287231..1288379	+	1149	WP_070423372.1	phage tail protein	-
JCR16_RS06320	1288476..1289393	+	918	WP_000094260.1	hypothetical protein	-
JCR16_RS06325	1289463..1289978	+	516	WP_038346477.1	hypothetical protein	-
JCR16_RS06330	1290304..1290486	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
JCR16_RS06335	1290579..1290983	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JCR16_RS06340	1291076..1291837	+	762	WP_000910437.1	hypothetical protein	-
JCR16_RS06345	1291903..1292280	+	378	WP_016062490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1204786..1304891	100105

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T184193 WP_000838146.1 NZ_CP066237:1290304-1290486 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T184193 NZ_CP087564:2549429-2549893 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT184193 WP_000966688.1 NZ_CP066237:1290579-1290983 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT184193 NZ_CP087564:2549094-2549429 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6