Detailed information of TA system TA184192

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 450040..450693
• Replicon: chromosome
• Accession: NZ_CP066237
• Organism: Acinetobacter baumannii strain G20AB007

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JCR16_RS02200
• Protein ID: WP_000607077.1
• Coordinates: 450304..450693 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: JCR16_RS02195
• Protein ID: WP_001288210.1
• Coordinates: 450040..450297 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR16_RS02175	445556..446563	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
JCR16_RS02180	446582..446959	+	378	WP_001216380.1	50S ribosomal protein L17	-
JCR16_RS02185	447141..448631	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
JCR16_RS02190	448680..449852	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
JCR16_RS02195	450040..450297	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
JCR16_RS02200	450304..450693	+	390	WP_000607077.1	membrane protein	Toxin
JCR16_RS02205	451463..452548	+	1086	WP_000049106.1	hypothetical protein	-
JCR16_RS02210	452626..453192	+	567	WP_000651538.1	rhombosortase	-
JCR16_RS02215	453380..455575	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T184192 WP_000607077.1 NZ_CP066237:450304-450693 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T184192 NZ_CP087564:c2506549-2506235 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT184192 WP_001288210.1 NZ_CP066237:450040-450297 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT184192 NZ_CP087564:c2506238-2505822 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7