Detailed information of TA system TA184190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1290219..1290898
• Replicon: chromosome
• Accession: NZ_CP066235
• Organism: Acinetobacter baumannii strain G20AB009

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: JCR17_RS06325
• Protein ID: WP_000838146.1
• Coordinates: 1290219..1290401 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: JCR17_RS06330
• Protein ID: WP_000966688.1
• Coordinates: 1290494..1290898 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR17_RS06285	1285333..1285737	+	405	WP_000247948.1	hypothetical protein	-
JCR17_RS06290	1285709..1286077	+	369	WP_002055488.1	hypothetical protein	-
JCR17_RS06295	1286079..1286477	+	399	WP_001251850.1	hypothetical protein	-
JCR17_RS06300	1286479..1286697	+	219	WP_070423369.1	hypothetical protein	-
JCR17_RS06305	1286793..1287146	+	354	WP_015451444.1	hypothetical protein	-
JCR17_RS06310	1287146..1288294	+	1149	WP_070423372.1	phage tail protein	-
JCR17_RS06315	1288391..1289308	+	918	WP_000094260.1	hypothetical protein	-
JCR17_RS06320	1289378..1289893	+	516	WP_038346477.1	hypothetical protein	-
JCR17_RS06325	1290219..1290401	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
JCR17_RS06330	1290494..1290898	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JCR17_RS06335	1290991..1291752	+	762	WP_000910437.1	hypothetical protein	-
JCR17_RS06340	1291818..1292195	+	378	WP_016062490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1204701..1307096	102395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T184190 WP_000838146.1 NZ_CP066235:1290219-1290401 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T184190 NZ_CP087564:c2285488-2285081 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT184190 WP_000966688.1 NZ_CP066235:1290494-1290898 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT184190 NZ_CP087564:c2285735-2285469 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6