Detailed information of TA system TA184186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2706027..2706706
• Replicon: chromosome
• Accession: NZ_CP066232
• Organism: Acinetobacter baumannii strain G20AB010

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: JCR18_RS12935
• Protein ID: WP_000838146.1
• Coordinates: 2706524..2706706 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: JCR18_RS12930
• Protein ID: WP_000966688.1
• Coordinates: 2706027..2706431 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR18_RS12920	2704730..2705107	-	378	WP_016062490.1	hypothetical protein	-
JCR18_RS12925	2705173..2705934	-	762	WP_000910437.1	hypothetical protein	-
JCR18_RS12930	2706027..2706431	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JCR18_RS12935	2706524..2706706	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
JCR18_RS12940	2707032..2707547	-	516	WP_038346477.1	hypothetical protein	-
JCR18_RS12945	2707617..2708534	-	918	WP_000094260.1	hypothetical protein	-
JCR18_RS12950	2708631..2709779	-	1149	WP_070423372.1	phage tail protein	-
JCR18_RS12955	2709779..2710132	-	354	WP_015451444.1	hypothetical protein	-
JCR18_RS12960	2710228..2710446	-	219	WP_070423369.1	hypothetical protein	-
JCR18_RS12965	2710448..2710846	-	399	WP_001251850.1	hypothetical protein	-
JCR18_RS12970	2710848..2711216	-	369	WP_002055488.1	hypothetical protein	-
JCR18_RS12975	2711188..2711592	-	405	WP_000247948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2692119..2790491	98372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T184186 WP_000838146.1 NZ_CP066232:c2706706-2706524 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T184186 NZ_CP087564:c1240693-1240439 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT184186 WP_000966688.1 NZ_CP066232:c2706431-2706027 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT184186 NZ_CP087564:c1240941-1240690 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6