Detailed information of TA system TA184183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1282127..1282806
• Replicon: chromosome
• Accession: NZ_CP066229
• Organism: Acinetobacter baumannii strain G20AB011

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: JCR19_RS06295
• Protein ID: WP_000838146.1
• Coordinates: 1282127..1282309 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: JCR19_RS06300
• Protein ID: WP_000966688.1
• Coordinates: 1282402..1282806 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR19_RS06255	1277241..1277645	+	405	WP_000247948.1	hypothetical protein	-
JCR19_RS06260	1277617..1277985	+	369	WP_002055488.1	hypothetical protein	-
JCR19_RS06265	1277987..1278385	+	399	WP_001251850.1	hypothetical protein	-
JCR19_RS06270	1278387..1278605	+	219	WP_070423369.1	hypothetical protein	-
JCR19_RS06275	1278701..1279054	+	354	WP_015451444.1	hypothetical protein	-
JCR19_RS06280	1279054..1280202	+	1149	WP_070423372.1	phage tail protein	-
JCR19_RS06285	1280299..1281216	+	918	WP_000094260.1	hypothetical protein	-
JCR19_RS06290	1281286..1281801	+	516	WP_038346477.1	hypothetical protein	-
JCR19_RS06295	1282127..1282309	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
JCR19_RS06300	1282402..1282806	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JCR19_RS06305	1282899..1283660	+	762	WP_000910437.1	hypothetical protein	-
JCR19_RS06310	1283726..1284103	+	378	WP_016062490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1195615..1296714	101099

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T184183 WP_000838146.1 NZ_CP066229:1282127-1282309 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T184183 NZ_CP087564:c746211-745924 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT184183 WP_000966688.1 NZ_CP066229:1282402-1282806 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT184183 NZ_CP087564:c746450-746211 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6