184179

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1314905..1315821 Replicon chromosome
Accession NZ_CP066219
Organism Bacillus siamensis strain B28

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag JD965_RS07025 Protein ID WP_045925708.1
Coordinates 1315075..1315821 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag JD965_RS07020 Protein ID WP_003154807.1
Coordinates 1314905..1315075 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JD965_RS06975 1310208..1310480 + 273 WP_064778770.1 hypothetical protein -
JD965_RS06980 1310483..1311712 + 1230 WP_198698741.1 hypothetical protein -
JD965_RS06985 1311725..1312150 + 426 WP_198698742.1 hypothetical protein -
JD965_RS06990 1312155..1312352 + 198 WP_045925711.1 XkdX family protein -
JD965_RS06995 1312401..1313162 + 762 WP_198698743.1 phage portal protein -
JD965_RS07000 1313214..1313477 + 264 WP_003154815.1 hemolysin XhlA family protein -
JD965_RS07005 1313491..1313754 + 264 WP_016936430.1 phage holin -
JD965_RS07010 1313768..1314646 + 879 WP_198698744.1 N-acetylmuramoyl-L-alanine amidase -
JD965_RS07015 1314683..1314808 - 126 WP_141228459.1 hypothetical protein -
JD965_RS07020 1314905..1315075 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
JD965_RS07025 1315075..1315821 - 747 WP_045925708.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
JD965_RS07030 1315928..1316926 - 999 WP_032874611.1 inorganic phosphate transporter -
JD965_RS07035 1316939..1317556 - 618 WP_032874614.1 DUF47 domain-containing protein -
JD965_RS07040 1317841..1319157 - 1317 WP_049628328.1 amino acid permease -
JD965_RS07045 1319478..1320428 + 951 WP_016936424.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29112.59 Da        Isoelectric Point: 4.6947

>T184179 WP_045925708.1 NZ_CP066219:c1315821-1315075 [Bacillus siamensis]
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFSAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

>T184179 NZ_CP087564:c368655-368548 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT184179 WP_003154807.1 NZ_CP066219:c1315075-1314905 [Bacillus siamensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp

>AT184179 NZ_CP087564:368702-368768 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References