Detailed information of TA system TA184177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 3119725..3120711
• Replicon: chromosome
• Accession: NZ_CP066218
• Organism: Mycolicibacterium sp. LJ126

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: I7X18_RS14535
• Protein ID: WP_193047993.1
• Coordinates: 3119725..3120303 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: I7X18_RS14540
• Protein ID: WP_193047992.1
• Coordinates: 3120319..3120711 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7X18_RS14525	3114780..3117329	-	2550	WP_193047995.1	helix-turn-helix transcriptional regulator	-
I7X18_RS14530	3118106..3119638	-	1533	WP_193047994.1	peroxidase	-
I7X18_RS14535	3119725..3120303	-	579	WP_193047993.1	zeta toxin family protein	Toxin
I7X18_RS14540	3120319..3120711	-	393	WP_193047992.1	hypothetical protein	Antitoxin
I7X18_RS14545	3120793..3121554	-	762	WP_193047991.1	SDR family oxidoreductase	-
I7X18_RS14550	3121564..3122577	-	1014	WP_193047990.1	acetamidase/formamidase family protein	-
I7X18_RS14555	3122730..3123371	-	642	WP_193047989.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
I7X18_RS14560	3123402..3124007	-	606	WP_193047988.1	class I SAM-dependent methyltransferase	-
I7X18_RS14565	3124090..3124314	+	225	WP_193047987.1	hypothetical protein	-
I7X18_RS14570	3124334..3124834	-	501	WP_193047986.1	polyketide cyclase	-
I7X18_RS14575	3124939..3125565	+	627	WP_193047985.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21052.02 Da
• Isoelectric Point: 8.9781

>T184177 WP_193047993.1 NZ_CP066218:c3120303-3119725 [Mycolicibacterium sp. LJ126]
MHRLDLVVGPNGAGKSTFVAFTLGPLLPGSPFLNADEIAKQRWPTDAERHSYQAARVAAATRTALIEAGRSFIAETVFSH
PSKLDLVDEALARDYTVVLHVLLIPEDLAVERVKHRVLAGGHNVAEEKIRERHRRLWDLVVRAIGSCDSATVYDNSDRKG
PRIVAQFAGGDPIGAPAWPAWTPAPLRTRWPA

Nucleotide

• Length: 579 bp

>T184177 NZ_CP087564:c367585-367478 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13645.97 Da
• Isoelectric Point: 4.4185

>AT184177 WP_193047992.1 NZ_CP066218:c3120711-3120319 [Mycolicibacterium sp. LJ126]
MADVADRVTRVAADLIESAAAEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAALAGEADLSTLTSEEGVVFNAEI
SAAIEEQLAGADYGNLLAAQGVTTVALDEEGRIVQYRPDGTSVVLDDTSA

Nucleotide

• Length: 393 bp

>AT184177 NZ_CP087564:367633-367699 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC