Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-vapB/RelE-VapB
Location 1580153..1580746 Replicon chromosome
Accession NZ_CP066218
Organism Mycolicibacterium sp. LJ126

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I7X18_RS07485 Protein ID WP_193047714.1
Coordinates 1580153..1580416 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I7X18_RS07490 Protein ID WP_193047713.1
Coordinates 1580540..1580746 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7X18_RS07455 1575705..1576262 - 558 WP_193047720.1 lipid droplet-associated protein -
I7X18_RS07460 1576316..1577317 + 1002 WP_193047719.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
I7X18_RS07465 1577351..1577557 + 207 WP_193047718.1 zinc-ribbon domain-containing protein -
I7X18_RS07470 1577561..1578691 - 1131 WP_193047717.1 hypothetical protein -
I7X18_RS07475 1578776..1579849 + 1074 WP_193047716.1 redox-regulated ATPase YchF -
I7X18_RS07480 1579881..1580156 + 276 WP_193047715.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
I7X18_RS07485 1580153..1580416 + 264 WP_193047714.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I7X18_RS07490 1580540..1580746 + 207 WP_193047713.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I7X18_RS07495 1580969..1581319 + 351 WP_193047712.1 DUF1801 domain-containing protein -
I7X18_RS07500 1581285..1581521 + 237 WP_193047711.1 ester cyclase -
I7X18_RS07505 1581587..1581766 + 180 WP_193047710.1 hypothetical protein -
I7X18_RS07510 1581763..1582437 - 675 WP_193047915.1 guanylate cyclase -
I7X18_RS07515 1582479..1582640 + 162 WP_193047709.1 hypothetical protein -
I7X18_RS07520 1582607..1583422 - 816 WP_193047708.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(35-86)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-42)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10188.77 Da        Isoelectric Point: 10.6029

>T184176 WP_193047714.1 NZ_CP066218:1580153-1580416 [Mycolicibacterium sp. LJ126]
MSYRVELTRAAKRALTESLPDTVAVACWEFIRGPLAENPYRVGKPLRGELEGRFSARRGEFRVIYQVFDDRVVVRVIHIG
HRRDIYR

Download         Length: 264 bp

>T184176 NZ_CP087393:6751-7101 [Pectobacterium parvum]
ATGTGGGAAGTAATAACGACAGAGTGCTTCGACGCCTGGTTTTTAACTCAAGATGATTCACTGAGAGAATCGGTTTACGA
GGCAATGGGGATCTTAGAGAAATTCGGACCTAAGCTCGGCAGGCCATATGTAGACACATTAAACGGCTCAGATTTTCCGA
ATATGAAAGAGTTACGTGTTCAACATGCAGGTAAACCAATAAGAGCATTCTTTGCTTTTGATCCGACACGTAAAGCTATC
GTGTTATGTGCCGGAGATAAGACCGGGATAAACGAGAAGCGATTCTACAGAGATATGATTCGACTTGCCGATTCTGAATA
CCTAAAACATCTGGCTAACCTGGAGAAATAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7391.38 Da        Isoelectric Point: 7.0138

>AT184176 WP_193047713.1 NZ_CP066218:1580540-1580746 [Mycolicibacterium sp. LJ126]
VRTTVTIDDELLAKAAELTGVKEDVALLRRGLQTLIRVESARRLAALGGTDPQAHAAPRRREPTESTE

Download         Length: 207 bp

>AT184176 NZ_CP087393:7104-7403 [Pectobacterium parvum]
ATGGCGACATACAGAGAGCTACTGGAAAAAGAGAGTCCGGAAATGCAGGCTCGCGTAGCGGCGCGGGTCGAAGAGACAAG
CCTGGTTATTGCCCTTAGTCAGCTACGTGATGAATTAGAGATCTCTCAGACAGAACTGGCACGGGCGATTGGCATATCCC
AACCAACACTGGCCAAGATGGAGAATCCTGAAAATGACCCTCGTCTTTCCACGTTAAAACGTTATGTAGCAGCATTAGGT
GGAGAACTGAGCATTGATGTCACGTTACCGACAGGGAAACGTGTCGCATTTCATCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References