Detailed information of TA system TA184176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-vapB/RelE-VapB
• Location: 1580153..1580746
• Replicon: chromosome
• Accession: NZ_CP066218
• Organism: Mycolicibacterium sp. LJ126

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I7X18_RS07485
• Protein ID: WP_193047714.1
• Coordinates: 1580153..1580416 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I7X18_RS07490
• Protein ID: WP_193047713.1
• Coordinates: 1580540..1580746 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7X18_RS07455	1575705..1576262	-	558	WP_193047720.1	lipid droplet-associated protein	-
I7X18_RS07460	1576316..1577317	+	1002	WP_193047719.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
I7X18_RS07465	1577351..1577557	+	207	WP_193047718.1	zinc-ribbon domain-containing protein	-
I7X18_RS07470	1577561..1578691	-	1131	WP_193047717.1	hypothetical protein	-
I7X18_RS07475	1578776..1579849	+	1074	WP_193047716.1	redox-regulated ATPase YchF	-
I7X18_RS07480	1579881..1580156	+	276	WP_193047715.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
I7X18_RS07485	1580153..1580416	+	264	WP_193047714.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I7X18_RS07490	1580540..1580746	+	207	WP_193047713.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
I7X18_RS07495	1580969..1581319	+	351	WP_193047712.1	DUF1801 domain-containing protein	-
I7X18_RS07500	1581285..1581521	+	237	WP_193047711.1	ester cyclase	-
I7X18_RS07505	1581587..1581766	+	180	WP_193047710.1	hypothetical protein	-
I7X18_RS07510	1581763..1582437	-	675	WP_193047915.1	guanylate cyclase	-
I7X18_RS07515	1582479..1582640	+	162	WP_193047709.1	hypothetical protein	-
I7X18_RS07520	1582607..1583422	-	816	WP_193047708.1	adenylate/guanylate cyclase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (35-86)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-42)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10188.77 Da
• Isoelectric Point: 10.6029

>T184176 WP_193047714.1 NZ_CP066218:1580153-1580416 [Mycolicibacterium sp. LJ126]
MSYRVELTRAAKRALTESLPDTVAVACWEFIRGPLAENPYRVGKPLRGELEGRFSARRGEFRVIYQVFDDRVVVRVIHIG
HRRDIYR

Nucleotide

• Length: 264 bp

>T184176 NZ_CP087393:6751-7101 [Pectobacterium parvum]
ATGTGGGAAGTAATAACGACAGAGTGCTTCGACGCCTGGTTTTTAACTCAAGATGATTCACTGAGAGAATCGGTTTACGA
GGCAATGGGGATCTTAGAGAAATTCGGACCTAAGCTCGGCAGGCCATATGTAGACACATTAAACGGCTCAGATTTTCCGA
ATATGAAAGAGTTACGTGTTCAACATGCAGGTAAACCAATAAGAGCATTCTTTGCTTTTGATCCGACACGTAAAGCTATC
GTGTTATGTGCCGGAGATAAGACCGGGATAAACGAGAAGCGATTCTACAGAGATATGATTCGACTTGCCGATTCTGAATA
CCTAAAACATCTGGCTAACCTGGAGAAATAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7391.38 Da
• Isoelectric Point: 7.0138

>AT184176 WP_193047713.1 NZ_CP066218:1580540-1580746 [Mycolicibacterium sp. LJ126]
VRTTVTIDDELLAKAAELTGVKEDVALLRRGLQTLIRVESARRLAALGGTDPQAHAAPRRREPTESTE

Nucleotide

• Length: 207 bp

>AT184176 NZ_CP087393:7104-7403 [Pectobacterium parvum]
ATGGCGACATACAGAGAGCTACTGGAAAAAGAGAGTCCGGAAATGCAGGCTCGCGTAGCGGCGCGGGTCGAAGAGACAAG
CCTGGTTATTGCCCTTAGTCAGCTACGTGATGAATTAGAGATCTCTCAGACAGAACTGGCACGGGCGATTGGCATATCCC
AACCAACACTGGCCAAGATGGAGAATCCTGAAAATGACCCTCGTCTTTCCACGTTAAAACGTTATGTAGCAGCATTAGGT
GGAGAACTGAGCATTGATGTCACGTTACCGACAGGGAAACGTGTCGCATTTCATCTCTAA