Detailed information of TA system TA184174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-CcdA
• Location: 1050200..1050828
• Replicon: chromosome
• Accession: NZ_CP066218
• Organism: Mycolicibacterium sp. LJ126

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I7X18_RS04935
• Protein ID: WP_193044285.1
• Coordinates: 1050421..1050828 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I7X18_RS04930
• Protein ID: WP_193044286.1
• Coordinates: 1050200..1050418 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7X18_RS04920	1045633..1049007	+	3375	WP_193044288.1	AAA family ATPase	-
I7X18_RS04925	1049004..1050167	+	1164	WP_193044287.1	DUF3322 and DUF2220 domain-containing protein	-
I7X18_RS04930	1050200..1050418	+	219	WP_193044286.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
I7X18_RS04935	1050421..1050828	+	408	WP_193044285.1	PIN domain-containing protein	Toxin
I7X18_RS04940	1051015..1051254	+	240	WP_193044284.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
I7X18_RS04945	1051251..1051685	+	435	WP_193044283.1	type II toxin-antitoxin system VapC family toxin	-
I7X18_RS04950	1051693..1053693	-	2001	WP_193044977.1	oligopeptide transporter, OPT family	-
I7X18_RS04955	1054261..1054563	+	303	WP_193044282.1	WXG100 family type VII secretion target	-
I7X18_RS04960	1054563..1054850	+	288	WP_193044281.1	WXG100 family type VII secretion target	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1033119..1058050	24931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (10-126)

Antitoxin

• Post-segregation antitoxin CcdA (3-47)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14619.85 Da
• Isoelectric Point: 8.6766

>T184174 WP_193044285.1 NZ_CP066218:1050421-1050828 [Mycolicibacterium sp. LJ126]
MSSPSPRKQVVIDASAMVDLLARAGDRYSAVRARLARTVMHAPAHFDAEVLSALGRLQRAGALTVVEVDAALDELRRAPV
TRHDLTPLVVGAWARRDTLRLADALYVELADTAGLTLLTTDQRLARAWPSADVII

Nucleotide

• Length: 408 bp

>T184174 NZ_CP087392:c4418749-4418438 [Pectobacterium parvum]
ATGCATGTTATTTCGCGGGCACCTTTCGACACTGCAACCACTCAGTTTCCGAATCAGGCGGCAGCACTTGATGACCTATA
TCGGGTTATCAAACGCGAAATGTATGCAACGCCGGACGATATGAAAAAACGCTTCCCCAGTCTAGATAGGATGAAATATC
GGGAAAAATGGTGGGTTATTGATATTGGTGGCGGGCATCTTCGAGTGATGTTTTTTGCTGATTTTGAGCGAGGGAAAATC
TTCATCAAGCACATCACATCCCATGCAGAGTACGATAGGCTGACAGAGTATTACCGGAGGAATAAAGAATGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 7631.43 Da
• Isoelectric Point: 4.3547

>AT184174 WP_193044286.1 NZ_CP066218:1050200-1050418 [Mycolicibacterium sp. LJ126]
MARLNVYVPDDLAEHARARGLNVSALTQAAIRAELEDAATDTWLESLDAKSTGARHGDVLAAIDAARDELGT

Nucleotide

• Length: 219 bp

>AT184174 NZ_CP087392:c4418441-4418025 [Pectobacterium parvum]
ATGATGTACGCAGACGCCATCAAGGCAGCTAACAACCTGACGAGTATCGTACCATTCCTCGGAGGCAGCGCCTCTCGTAA
GGATTATGAGGATGCGCTGAAACTAACCGAATACCTGATCGAGAGTGAACCTGACAGTCCGCTAATCGATATGCTGACTG
CCAAAATTGACAAATACGAAGATGATGCGCCGGAGTTTGCAGCCTTCAACGAACGTGTTAAAGCACTCCCAGCAGGTATC
GCTTTACTGCGCGTCCTTATGGATCAGCATCAGCTAACGCAGAGTGATTTTGAAGCTGAGATTGGTAAAAAGTCTCTGGT
ATCCCGCATTCTAAAAGGTGAGCGCACTCTAACGCTGGATCACATGAGAGCGCTTGCTAAACGATTCAATATTCCCGTGA
GTGCTTTTGTTGATTGA