Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 92509..93050 Replicon chromosome
Accession NZ_CP066218
Organism Mycolicibacterium sp. LJ126

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag I7X18_RS00455 Protein ID WP_193045220.1
Coordinates 92757..93050 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag I7X18_RS00450 Protein ID WP_193045221.1
Coordinates 92509..92760 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7X18_RS00425 87647..88078 + 432 WP_193045225.1 Hsp20/alpha crystallin family protein -
I7X18_RS00430 88138..88932 - 795 WP_198730510.1 IclR family transcriptional regulator -
I7X18_RS00435 89084..89830 + 747 WP_193045224.1 SDR family oxidoreductase -
I7X18_RS00440 89872..90774 + 903 WP_193045223.1 SDR family NAD(P)-dependent oxidoreductase -
I7X18_RS00445 91080..92108 - 1029 WP_193045222.1 alpha/beta fold hydrolase -
I7X18_RS00450 92509..92760 + 252 WP_193045221.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
I7X18_RS00455 92757..93050 + 294 WP_193045220.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I7X18_RS00460 93142..93266 - 125 Protein_88 IS3 family transposase -
I7X18_RS00465 93410..93898 + 489 WP_193045219.1 hypothetical protein -
I7X18_RS00470 93948..94538 - 591 WP_193045218.1 TetR/AcrR family transcriptional regulator -
I7X18_RS00475 94596..95603 + 1008 WP_193045217.1 NAD-dependent epimerase/dehydratase family protein -
I7X18_RS00480 95603..97819 + 2217 WP_193045216.1 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11258.80 Da        Isoelectric Point: 6.8515

>T184173 WP_193045220.1 NZ_CP066218:92757-93050 [Mycolicibacterium sp. LJ126]
VNRVVFSPAAQVDLEQIWDCTCDRWDADQAERYIRVLQRAVERVADNPLIGRACDEVRVGYRRHAVGSHTLYYRVAGDLI
VVVRVLHKRMDVDQHLD

Download         Length: 294 bp

>T184173 NZ_CP087392:4372373-4372627 [Pectobacterium parvum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATAGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTGGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9092.99 Da        Isoelectric Point: 4.6536

>AT184173 WP_193045221.1 NZ_CP066218:92509-92760 [Mycolicibacterium sp. LJ126]
MGKNTSFSLDTHFNEFIEGEVASGRYGSASEVVRAALRLLEDRETRLDALRQALGRGENSGEATAIDFDAFVERKAVESR
AAQ

Download         Length: 252 bp

>AT184173 NZ_CP087392:4372125-4372376 [Pectobacterium parvum]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGATCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTGATGTCCCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References