Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 57104..57888 Replicon chromosome
Accession NZ_CP066218
Organism Mycolicibacterium sp. LJ126

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag I7X18_RS00265 Protein ID WP_193045254.1
Coordinates 57104..57613 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag I7X18_RS00270 Protein ID WP_193045253.1
Coordinates 57610..57888 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7X18_RS00245 52985..54730 - 1746 WP_193045257.1 ATP-binding protein -
I7X18_RS00250 54853..55437 - 585 WP_193045860.1 metallophosphoesterase -
I7X18_RS00255 55628..56467 - 840 WP_193045256.1 hypothetical protein -
I7X18_RS00260 56464..57096 - 633 WP_193045255.1 hypothetical protein -
I7X18_RS00265 57104..57613 - 510 WP_193045254.1 GNAT family N-acetyltransferase Toxin
I7X18_RS00270 57610..57888 - 279 WP_193045253.1 DUF1778 domain-containing protein Antitoxin
I7X18_RS00275 58065..58316 + 252 WP_193045252.1 hypothetical protein -
I7X18_RS00280 58321..58497 - 177 WP_193045251.1 hypothetical protein -
I7X18_RS00285 58655..58939 + 285 WP_193045250.1 hypothetical protein -
I7X18_RS00290 59834..60898 + 1065 WP_193045249.1 hypothetical protein -
I7X18_RS00295 61171..62682 + 1512 WP_193045248.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 40793..70059 29266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-145)

Antitoxin

Vibrio phage ICP1, Orf50

(4-91)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18423.11 Da        Isoelectric Point: 7.4355

>T184172 WP_193045254.1 NZ_CP066218:c57613-57104 [Mycolicibacterium sp. LJ126]
VSGYGAPRPISEHDVVADFDSGEPSLDEYLRGRALANHVEGASRCFVTCRDGRVVGFYALASAAVERAGTPGRVRRNMPD
PVPVILLSRLAIDRKEQGQGLGAALLRDAIIRAVAAAEIIGVRALLVHALHERAREFYAHFDFEPSPTDPLHLLLLIKDA
RALLDRPQK

Download         Length: 510 bp

>T184172 NZ_CP087392:4372125-4372376 [Pectobacterium parvum]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGATCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTGATGTCCCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10432.00 Da        Isoelectric Point: 4.8537

>AT184172 WP_193045253.1 NZ_CP066218:c57888-57610 [Mycolicibacterium sp. LJ126]
MNGMAIKTERFAVRLTAEQDALIRRAAEVEGMDLTNFTVTATLARAREVLADRRLFMLDASAWSEFVSVLDRPVSQKPRL
EKLFAEPSIFDE

Download         Length: 279 bp

>AT184172 NZ_CP087392:4372373-4372627 [Pectobacterium parvum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATAGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTGGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References