Detailed information of TA system TA184172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 57104..57888
• Replicon: chromosome
• Accession: NZ_CP066218
• Organism: Mycolicibacterium sp. LJ126

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: I7X18_RS00265
• Protein ID: WP_193045254.1
• Coordinates: 57104..57613 (-)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: I7X18_RS00270
• Protein ID: WP_193045253.1
• Coordinates: 57610..57888 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7X18_RS00245	52985..54730	-	1746	WP_193045257.1	ATP-binding protein	-
I7X18_RS00250	54853..55437	-	585	WP_193045860.1	metallophosphoesterase	-
I7X18_RS00255	55628..56467	-	840	WP_193045256.1	hypothetical protein	-
I7X18_RS00260	56464..57096	-	633	WP_193045255.1	hypothetical protein	-
I7X18_RS00265	57104..57613	-	510	WP_193045254.1	GNAT family N-acetyltransferase	Toxin
I7X18_RS00270	57610..57888	-	279	WP_193045253.1	DUF1778 domain-containing protein	Antitoxin
I7X18_RS00275	58065..58316	+	252	WP_193045252.1	hypothetical protein	-
I7X18_RS00280	58321..58497	-	177	WP_193045251.1	hypothetical protein	-
I7X18_RS00285	58655..58939	+	285	WP_193045250.1	hypothetical protein	-
I7X18_RS00290	59834..60898	+	1065	WP_193045249.1	hypothetical protein	-
I7X18_RS00295	61171..62682	+	1512	WP_193045248.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	40793..70059	29266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-91)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 18423.11 Da
• Isoelectric Point: 7.4355

>T184172 WP_193045254.1 NZ_CP066218:c57613-57104 [Mycolicibacterium sp. LJ126]
VSGYGAPRPISEHDVVADFDSGEPSLDEYLRGRALANHVEGASRCFVTCRDGRVVGFYALASAAVERAGTPGRVRRNMPD
PVPVILLSRLAIDRKEQGQGLGAALLRDAIIRAVAAAEIIGVRALLVHALHERAREFYAHFDFEPSPTDPLHLLLLIKDA
RALLDRPQK

Nucleotide

• Length: 510 bp

>T184172 NZ_CP087392:4372125-4372376 [Pectobacterium parvum]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGATCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTGATGTCCCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10432.00 Da
• Isoelectric Point: 4.8537

>AT184172 WP_193045253.1 NZ_CP066218:c57888-57610 [Mycolicibacterium sp. LJ126]
MNGMAIKTERFAVRLTAEQDALIRRAAEVEGMDLTNFTVTATLARAREVLADRRLFMLDASAWSEFVSVLDRPVSQKPRL
EKLFAEPSIFDE

Nucleotide

• Length: 279 bp

>AT184172 NZ_CP087392:4372373-4372627 [Pectobacterium parvum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATAGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTGGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA