184170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 218692..219221 Replicon chromosome
Accession NZ_CP066215
Organism Enterococcus faecium strain 18-042

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag I8F50_RS01080 Protein ID WP_002296560.1
Coordinates 218955..219221 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag I8F50_RS01075 Protein ID WP_002296559.1
Coordinates 218692..218955 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8F50_RS01065 (I8F50_01065) 216066..217889 + 1824 WP_002294202.1 APC family permease -
I8F50_RS01070 (I8F50_01070) 218031..218216 - 186 WP_002296558.1 transcriptional regulator -
I8F50_RS01075 (I8F50_01075) 218692..218955 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I8F50_RS01080 (I8F50_01080) 218955..219221 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
I8F50_RS01085 (I8F50_01085) 219422..219910 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
I8F50_RS01090 (I8F50_01090) 220451..221104 - 654 WP_002323018.1 ABC transporter permease -
I8F50_RS01095 (I8F50_01095) 221119..222036 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
I8F50_RS01100 (I8F50_01100) 222033..222674 - 642 WP_002293405.1 ABC transporter permease -
I8F50_RS01105 (I8F50_01105) 222678..223853 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T184170 WP_002296560.1 NZ_CP066215:218955-219221 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T184170 NZ_CP087392:4048620-4048928 [Pectobacterium parvum]
ATGCAATATAAAGTTTACCGTAATAACGGTAACAGCAACTCATACCCTTACCTGCTCAATGTCCAAAGTGACATCATTGG
GGAATTACATACCCGTCTGGTAATACCTTTGTTTCCATTAAACAAAGTTGCCAGACCACCAGCGCGAAGGCTAACGCCGA
TAGTCACTGTCGAAGGCAATGATTACCTGATAATGACCCATGAGATGGCGAGTGTACGCCGCTCACAACTTGGTCATGAA
GTGATGGATGCGCAGATGTACCGAAAAACAATCAAAGACGCCGTTGATTTCCTGCTGGATGGGTTCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT184170 WP_002296559.1 NZ_CP066215:218692-218955 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT184170 NZ_CP087392:4048378-4048617 [Pectobacterium parvum]
ATGCCCGTAACAAGCATTCGCCATAAAAAAACGGTCAGTGTGACGCTGGAACCCATGCTGCTCCAACAAGCACGTGAAGC
CGGGATTAACCTATCCGCAATACTCACCGAGGCGTTGAAGAGAGAAATTCGCCTTTCTGAAGGGGAAAAATGGAAGCAGC
AGAACCAGAAGGCACTGCAGGAACTAAACCGTATCACAGATAAACACGGCTTATTATCCGACGATGACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References