Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1986639..1987276 Replicon chromosome
Accession NZ_CP066203
Organism Methylacidimicrobium sp. B4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MacB4_RS09330 Protein ID WP_206863564.1
Coordinates 1986639..1987046 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MacB4_RS09335 Protein ID WP_024808843.1
Coordinates 1987043..1987276 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MacB4_RS09305 1981767..1984262 + 2496 WP_206863561.1 glycosyltransferase -
MacB4_RS09310 1984300..1984836 - 537 WP_206863562.1 inorganic diphosphatase -
MacB4_RS09315 1985024..1985353 + 330 WP_206863563.1 nucleotidyltransferase domain-containing protein -
MacB4_RS09320 1985759..1986313 + 555 WP_206865021.1 nucleotidyltransferase domain-containing protein -
MacB4_RS09325 1986264..1986590 + 327 Protein_1821 HEPN domain-containing protein -
MacB4_RS09330 1986639..1987046 - 408 WP_206863564.1 PIN domain-containing protein Toxin
MacB4_RS09335 1987043..1987276 - 234 WP_024808843.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MacB4_RS09340 1987492..1989039 + 1548 WP_206863565.1 aldehyde dehydrogenase family protein -
MacB4_RS09345 1989036..1989695 - 660 WP_206863566.1 YceI family protein -
MacB4_RS09350 1989750..1990742 - 993 WP_206863567.1 glycosyltransferase -
MacB4_RS09355 1990739..1991668 - 930 WP_206863568.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(4-128)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-42)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15383.90 Da        Isoelectric Point: 6.9800

>T184169 WP_206863564.1 NZ_CP066203:c1987046-1986639 [Methylacidimicrobium sp. B4]
MKILLDTQCWLWMEAEPERLNPQVRDLLLDPAHALYLSAASAWEISIKIAIGKLRLPSPPSAYLAERMGREKLRPLSIEH
EHALLAGSLPPHHRDPFDRMLVAQALREKLTLLSADPIFARYEAAVLWADRESSR

Download         Length: 408 bp

>T184169 NZ_CP087392:c3687180-3686866 [Pectobacterium parvum]
ATGCAAAAAATGCGCAGCATTCATAGCTTTCGGGATCAGTGGCTGGAAGATTTTTTTATGTATGGCAAGTCGCATAAAAA
GATACCTGCCGATGTGGTTACATCCTTGTCCCGCAAGCTGGATATCATCAACGCGGCGGTTTCAGCAAAAGACCTAAGAT
CGCCGCCGGGGAACCGATACGAGAACCTTAATCCGCCATTGGGGGAATATTCATCCATCAGAGTAAATATCCAATATCGC
CTGATTTTTAAATGGGTTGATGGTAAAGCAGAGGATATCTATCTTGACGACCATGGTTATAAAAAGCACAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8597.12 Da        Isoelectric Point: 8.8469

>AT184169 WP_024808843.1 NZ_CP066203:c1987276-1987043 [Methylacidimicrobium sp. B4]
MQTVTVHEAKTHLSRLLRKVAGGEEVLVLRGKVPIAKIVPLDIDHAPRRLGLDKGRIWIAPDFDAPLPEEVLRAFEP

Download         Length: 234 bp

>AT184169 NZ_CP087392:c3686811-3686470 [Pectobacterium parvum]
ATGGCACAGGCACAACGCAAGCCGACATCCGTAGGCGATGTCCTGTTATATGAATATCTAGAACCTACAGGTTTGAAGAT
TAATGACTTGGCGGAAATGCTGAATGTCCACCGTAACACAATCAGCGCACTGGTTAACAACAACCGTAAGTTAACGGTTG
ATATGGCATTCCGGTTGGCGAAAGCATTTGATACGTCAGTTGATTTCTGGCTGAACCTGCAAAATAGCGTTGACGTGTGG
GAAGTGGAAAACGACGCACGAACTCAGGAAGAAATTAGCCGGATCACTACGCTGGAAGATTTTCTGGCGCAACGTGATGA
AAATGTGAAAGACGTATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References