Detailed information of TA system TA184167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1172068..1172557
• Replicon: chromosome
• Accession: NZ_CP066203
• Organism: Methylacidimicrobium sp. B4

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: MacB4_RS05650
• Protein ID: WP_206864858.1
• Coordinates: 1172068..1172346 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: MacB4_RS05655
• Protein ID: WP_206864859.1
• Coordinates: 1172330..1172557 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MacB4_RS05640	1169040..1171061	+	2022	WP_206864857.1	DUF1926 domain-containing protein	-
MacB4_RS05645	1171100..1171534	+	435	WP_024808132.1	hypothetical protein	-
MacB4_RS05650	1172068..1172346	-	279	WP_206864858.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MacB4_RS05655	1172330..1172557	-	228	WP_206864859.1	ribbon-helix-helix protein, CopG family	Antitoxin
MacB4_RS05660	1173141..1173935	-	795	WP_206864860.1	hypothetical protein	-
MacB4_RS05665	1173986..1174210	+	225	WP_206864861.1	hypothetical protein	-
MacB4_RS05670	1174207..1174515	-	309	WP_206864862.1	hypothetical protein	-
MacB4_RS05675	1174512..1174721	-	210	WP_206864863.1	hypothetical protein	-
MacB4_RS05680	1174737..1175039	-	303	WP_206864864.1	cytochrome C oxidase subunit IV family protein	-
MacB4_RS05685	1175067..1175864	-	798	WP_206864958.1	cytochrome c oxidase subunit 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10852.83 Da
• Isoelectric Point: 11.3617

>T184167 WP_206864858.1 NZ_CP066203:c1172346-1172068 [Methylacidimicrobium sp. B4]
MAWRVELSTLARKTLEKLDPPIARRILLFLHERVAPLDDPRGIGERLQGPRFGELWRYRVGDYRLIAKIEDGALRILVLL
IGHRRNIYRKQP

Nucleotide

• Length: 279 bp

>T184167 NZ_CP087392:3455095-3455298 [Pectobacterium parvum]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACCCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTGGCAGAACTGACGATGAACAAAC
TCTACGACAAAGTGCCTACTGCGGTATGGCGATACGTCCGTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8591.81 Da
• Isoelectric Point: 4.3813

>AT184167 WP_206864859.1 NZ_CP066203:c1172557-1172330 [Methylacidimicrobium sp. B4]
MPLSVRLPGDLESRLQNLADRTGRSKTYYVIEAIREYIEVMEDIYLAEGEIEAMRAGRSEALPLEEVMKHYGMEG

Nucleotide

• Length: 228 bp

>AT184167 NZ_CP087392:3454673-3455041 [Pectobacterium parvum]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGTGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTGGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGATGCTGAACTACGGCATTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA