Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 1972997..1973989 | Replicon | chromosome |
| Accession | NZ_CP066192 | ||
| Organism | Bacillus cytotoxicus strain E17.4 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A7GPN6 |
| Locus tag | JC775_RS09780 | Protein ID | WP_012094283.1 |
| Coordinates | 1972997..1973737 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A7GPN7 |
| Locus tag | JC775_RS09785 | Protein ID | WP_012094285.1 |
| Coordinates | 1973861..1973989 (+) | Length | 43 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JC775_RS09755 (JC775_09755) | 1968471..1969373 | + | 903 | WP_087098709.1 | BadF/BadG/BcrA/BcrD ATPase family protein | - |
| JC775_RS09760 (JC775_09760) | 1969397..1969726 | - | 330 | Protein_1871 | hypothetical protein | - |
| JC775_RS09765 (JC775_09765) | 1969921..1971225 | + | 1305 | WP_087098711.1 | DEAD/DEAH box helicase | - |
| JC775_RS09770 (JC775_09770) | 1971445..1971927 | + | 483 | WP_012094281.1 | helix-turn-helix domain-containing protein | - |
| JC775_RS09775 (JC775_09775) | 1972065..1972802 | + | 738 | WP_012094282.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| JC775_RS09780 (JC775_09780) | 1972997..1973737 | + | 741 | WP_012094283.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| JC775_RS09785 (JC775_09785) | 1973861..1973989 | + | 129 | WP_012094285.1 | hypothetical protein | Antitoxin |
| JC775_RS09790 (JC775_09790) | 1974066..1974242 | + | 177 | WP_087094925.1 | stage II sporulation protein SB | - |
| JC775_RS09795 (JC775_09795) | 1974401..1974946 | - | 546 | WP_087094926.1 | GNAT family N-acetyltransferase | - |
| JC775_RS09800 (JC775_09800) | 1974987..1975868 | - | 882 | WP_012094288.1 | aminoglycoside 6-adenylyltransferase | - |
| JC775_RS09805 (JC775_09805) | 1976074..1977543 | + | 1470 | WP_012094289.1 | aminoacyl-histidine dipeptidase | - |
| JC775_RS09810 (JC775_09810) | 1978133..1978384 | + | 252 | WP_012094290.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28628.30 Da Isoelectric Point: 6.7302
>T184159 WP_012094283.1 NZ_CP066192:1972997-1973737 [Bacillus cytotoxicus]
MTVTSVRIGLFFLVIFFLFLIFFYWRNEERYEERKQLIRKTWYGLFITSVTMYFMMKGIDLTLWKHILMVVAMVVFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTLIQNVNPAAFGTMEWETDAEYARSLNAFLDTYAEKIGAK
IVVFVTEEELNTNFRGVRSQFSITVSPESIEQLNEQKAVQIENVGIIPAKIIKDVYIIMDGQKNNLQDRDFENVYNLTIH
HSYFCK
MTVTSVRIGLFFLVIFFLFLIFFYWRNEERYEERKQLIRKTWYGLFITSVTMYFMMKGIDLTLWKHILMVVAMVVFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTLIQNVNPAAFGTMEWETDAEYARSLNAFLDTYAEKIGAK
IVVFVTEEELNTNFRGVRSQFSITVSPESIEQLNEQKAVQIENVGIIPAKIIKDVYIIMDGQKNNLQDRDFENVYNLTIH
HSYFCK
Download Length: 741 bp
>T184159 NZ_CP087392:c137346-136858 [Pectobacterium parvum]
ATGGAGTATTTAGACGTAAATGGTTGGAAAATCTGCTTTCATTCATGCTTTTTGCAGCAGATTGCAGAACTTGCTCAAAA
GGTTGTTGAGTTAAAAGCTGCAAAGCCCGATGAATACCTTGGCAAGAAGGAAACAAAGCTCCTACATGCGATTGAGCGTG
TGATTGAGGAATGGATAGCAGTCGATCCTCTCAATCCACAATACCGTCAGGGAGATACTTTAGGCGATGAATTCAAACAT
TGGTTCCGTGCCAAATTCTTGTCGCAGTTCCGTTTGTTTTATCGTTGCAGCGCGGAACATAAGACTATCATTATCGGTTG
GGTAAATGATTTCGATACGCTTCGCGCTTACGGTTCAAAGACAGATGCCTATAAGGTGTTTGCAGGGATGTTAAGGGCAG
GCGAACCGCCAGATGACTGGGAGAAACTACTCAACGAGGCAAAAGCAATTACTGCCACAACGTCTATTCCAGGTTTCCTT
GGAAAATAA
ATGGAGTATTTAGACGTAAATGGTTGGAAAATCTGCTTTCATTCATGCTTTTTGCAGCAGATTGCAGAACTTGCTCAAAA
GGTTGTTGAGTTAAAAGCTGCAAAGCCCGATGAATACCTTGGCAAGAAGGAAACAAAGCTCCTACATGCGATTGAGCGTG
TGATTGAGGAATGGATAGCAGTCGATCCTCTCAATCCACAATACCGTCAGGGAGATACTTTAGGCGATGAATTCAAACAT
TGGTTCCGTGCCAAATTCTTGTCGCAGTTCCGTTTGTTTTATCGTTGCAGCGCGGAACATAAGACTATCATTATCGGTTG
GGTAAATGATTTCGATACGCTTCGCGCTTACGGTTCAAAGACAGATGCCTATAAGGTGTTTGCAGGGATGTTAAGGGCAG
GCGAACCGCCAGATGACTGGGAGAAACTACTCAACGAGGCAAAAGCAATTACTGCCACAACGTCTATTCCAGGTTTCCTT
GGAAAATAA
Antitoxin
Download Length: 43 a.a. Molecular weight: 4984.43 Da Isoelectric Point: 3.9944
>AT184159 WP_012094285.1 NZ_CP066192:1973861-1973989 [Bacillus cytotoxicus]
VLKEYSNDFFKDEAEDTTDFSLIKGDTMQQVEELEEELKRRG
VLKEYSNDFFKDEAEDTTDFSLIKGDTMQQVEELEEELKRRG
Download Length: 129 bp
>AT184159 NZ_CP087392:c137712-137371 [Pectobacterium parvum]
ATGGCGATTCAAATTAATACGGCGGACGTGTCACTGCGCGCTGAGTCTCGACTCACCGAACGTAGTCAGACAACGATTCC
GGCAGCAATACGCGATGCTTTGCATCTCAAGCCAGGTGAATACATTAAGTACACCTTGCTTGCAGGTGGCAAAGTCATCA
TGTCTCGACAGGAAGAAGAACAGGACGACCCCGTTGTATCGCAGTTTCTAACTTTTCTCGAAAATGACATGAAGAAAAAC
CCACAGAACATCCACTCCATACCGGTGGCTTTCTGGGAAAGCGTCAAAGCATTAACTGCTGGAGTTGAGGTCGATTTAGA
TGCGCCGCTTACTGATGACTAA
ATGGCGATTCAAATTAATACGGCGGACGTGTCACTGCGCGCTGAGTCTCGACTCACCGAACGTAGTCAGACAACGATTCC
GGCAGCAATACGCGATGCTTTGCATCTCAAGCCAGGTGAATACATTAAGTACACCTTGCTTGCAGGTGGCAAAGTCATCA
TGTCTCGACAGGAAGAAGAACAGGACGACCCCGTTGTATCGCAGTTTCTAACTTTTCTCGAAAATGACATGAAGAAAAAC
CCACAGAACATCCACTCCATACCGGTGGCTTTCTGGGAAAGCGTCAAAGCATTAACTGCTGGAGTTGAGGTCGATTTAGA
TGCGCCGCTTACTGATGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|