Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3487113..3488105 Replicon chromosome
Accession NZ_CP066187
Organism Bacillus cytotoxicus strain E28.3

Toxin (Protein)


Gene name spoIISA Uniprot ID A7GPN6
Locus tag JC772_RS17630 Protein ID WP_012094283.1
Coordinates 3487113..3487853 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A7GPN7
Locus tag JC772_RS17635 Protein ID WP_012094285.1
Coordinates 3487977..3488105 (+) Length 43 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC772_RS17600 (JC772_17600) 3482253..3482518 + 266 Protein_3413 hypothetical protein -
JC772_RS17605 (JC772_17605) 3482588..3483490 + 903 WP_012094278.1 BadF/BadG/BcrA/BcrD ATPase family protein -
JC772_RS17610 (JC772_17610) 3483537..3483842 - 306 Protein_3415 hypothetical protein -
JC772_RS17615 (JC772_17615) 3484037..3485341 + 1305 WP_087094924.1 DEAD/DEAH box helicase -
JC772_RS17620 (JC772_17620) 3485561..3486043 + 483 WP_012094281.1 helix-turn-helix domain-containing protein -
JC772_RS17625 (JC772_17625) 3486181..3486918 + 738 WP_012094282.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
JC772_RS17630 (JC772_17630) 3487113..3487853 + 741 WP_012094283.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
JC772_RS17635 (JC772_17635) 3487977..3488105 + 129 WP_012094285.1 hypothetical protein Antitoxin
JC772_RS17640 (JC772_17640) 3488182..3488358 + 177 WP_087094925.1 stage II sporulation protein SB -
JC772_RS17645 (JC772_17645) 3488517..3489062 - 546 WP_087094926.1 GNAT family N-acetyltransferase -
JC772_RS17650 (JC772_17650) 3489103..3489984 - 882 WP_087094927.1 aminoglycoside 6-adenylyltransferase -
JC772_RS17655 (JC772_17655) 3490190..3491659 + 1470 WP_087094928.1 aminoacyl-histidine dipeptidase -
JC772_RS17660 (JC772_17660) 3492258..3492509 + 252 WP_012094290.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-244)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 247 a.a.        Molecular weight: 28628.30 Da        Isoelectric Point: 6.7302

>T184153 WP_012094283.1 NZ_CP066187:3487113-3487853 [Bacillus cytotoxicus]
MTVTSVRIGLFFLVIFFLFLIFFYWRNEERYEERKQLIRKTWYGLFITSVTMYFMMKGIDLTLWKHILMVVAMVVFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTLIQNVNPAAFGTMEWETDAEYARSLNAFLDTYAEKIGAK
IVVFVTEEELNTNFRGVRSQFSITVSPESIEQLNEQKAVQIENVGIIPAKIIKDVYIIMDGQKNNLQDRDFENVYNLTIH
HSYFCK

Download         Length: 741 bp

>T184153 NZ_CP087390:c3207786-3207403 [Enterobacter sp. AN-K1]
ATGCAAATTTCAACTGCACCGACCACGGAGCCTGTTTCGTCACGCCTGTCGCCTGTCGAGGTCTGGCAGATACTACTCAA
ACATCTTCTGGCACAACACTATGGTCTAACCCTTAATGACACTCCGTTCAGCGATGAAAGCACTATTCGTGAACATATCA
ATGCTGGTATCTCACTCAGCAACGCAGTGAATTTTATCGTCGAAAAATATGAGCTGGTACGTACTGACCATAGTGGATTT
ACGATTATGGAGCAGTCTCCCTTCATCAGCAGTATCGACATTCTTCGTGCCCGCCGGGCCACTGGATTGATGAAACGTCA
TGGTTATAAATCCATCAGCAATATCACTACTGGTCACCTTCTCCAGGAGCGACATTTACGATGA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4984.43 Da        Isoelectric Point: 3.9944

>AT184153 WP_012094285.1 NZ_CP066187:3487977-3488105 [Bacillus cytotoxicus]
VLKEYSNDFFKDEAEDTTDFSLIKGDTMQQVEELEEELKRRG

Download         Length: 129 bp

>AT184153 NZ_CP087390:c3208160-3207822 [Enterobacter sp. AN-K1]
ATGACTAAAGAACCTGTTCAGGAACACGTGTGGGGTTTACACAGTCAAACCGTTCCATCATTCAGCGCCCGGTTAGTTCA
GGAAGGTCGACGGCTGCATTTTCTGGCCGACCGTGCCACGCTTCTCGGCACATTCAGCCCGGAACAATCCGCAGCGCTGG
ATGCGATCTTCCCAGCATTAATCCGGGATATGGAAACCGCTCTGCTTAGCGGCAAACTCGACCCACGTGAGGCTAAACAA
TACATCTATATCCGCAACGGTTTAACCTGCGAGTCAGATACGTTGGGGAGTTGCGGTTATGTTTACATCGTAATTTATCC
TCAATCAGAAGCCAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A7GPN6


Antitoxin

Source ID Structure
AlphaFold DB A7GPN7

References