Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3094949..3095941 Replicon chromosome
Accession NZ_CP066185
Organism Bacillus cytotoxicus strain PDT2.12

Toxin (Protein)


Gene name spoIISA Uniprot ID A7GPN6
Locus tag JC773_RS15685 Protein ID WP_012094283.1
Coordinates 3094949..3095689 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A7GPN7
Locus tag JC773_RS15690 Protein ID WP_012094285.1
Coordinates 3095813..3095941 (+) Length 43 a.a.

Genomic Context

JC773_RS15660JC773_RS15670JC773_RS15675JC773_RS15680JC773_RS15685JC773_RS15690JC773_RS15695JC773_RS15710JC773_RS15715JC773_RS15665JC773_RS15700JC773_RS15705
Location: 3090422..3091324 (903 bp)
Type: Others
Protein ID: WP_210351571.1
Location: 3091873..3093177 (1305 bp)
Type: Others
Protein ID: WP_087098711.1
Location: 3093397..3093879 (483 bp)
Type: Others
Protein ID: WP_012094281.1
Location: 3094017..3094754 (738 bp)
Type: Others
Protein ID: WP_012094282.1
Location: 3094949..3095689 (741 bp)
Type: Toxin
Protein ID: WP_012094283.1
Location: 3095813..3095941 (129 bp)
Type: Antitoxin
Protein ID: WP_012094285.1
Location: 3096018..3096194 (177 bp)
Type: Others
Protein ID: WP_087094925.1
Location: 3098026..3099495 (1470 bp)
Type: Others
Protein ID: WP_012094289.1
Location: 3100085..3100336 (252 bp)
Type: Others
Protein ID: WP_012094290.1
Location: 3091348..3091677 (330 bp)
Type: Others
Protein ID: Protein_3024
Location: 3096353..3096898 (546 bp)
Type: Others
Protein ID: WP_087094926.1
Location: 3096939..3097820 (882 bp)
Type: Others
Protein ID: WP_012094288.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JC773_RS15660 (JC773_15660)3090422..3091324+903WP_210351571.1BadF/BadG/BcrA/BcrD ATPase family protein-
JC773_RS15665 (JC773_15665)3091348..3091677-330Protein_3024hypothetical protein-
JC773_RS15670 (JC773_15670)3091873..3093177+1305WP_087098711.1DEAD/DEAH box helicase-
JC773_RS15675 (JC773_15675)3093397..3093879+483WP_012094281.1helix-turn-helix domain-containing protein-
JC773_RS15680 (JC773_15680)3094017..3094754+738WP_012094282.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
JC773_RS15685 (JC773_15685)3094949..3095689+741WP_012094283.1type II toxin-antitoxin system SpoIISA family toxinToxin
JC773_RS15690 (JC773_15690)3095813..3095941+129WP_012094285.1hypothetical proteinAntitoxin
JC773_RS15695 (JC773_15695)3096018..3096194+177WP_087094925.1stage II sporulation protein SB-
JC773_RS15700 (JC773_15700)3096353..3096898-546WP_087094926.1GNAT family N-acetyltransferase-
JC773_RS15705 (JC773_15705)3096939..3097820-882WP_012094288.1aminoglycoside 6-adenylyltransferase-
JC773_RS15710 (JC773_15710)3098026..3099495+1470WP_012094289.1aminoacyl-histidine dipeptidase-
JC773_RS15715 (JC773_15715)3100085..3100336+252WP_012094290.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28628.30 Da        Isoelectric Point: 6.7302

>T184151 WP_012094283.1 NZ_CP066185:3094949-3095689 [Bacillus cytotoxicus]
MTVTSVRIGLFFLVIFFLFLIFFYWRNEERYEERKQLIRKTWYGLFITSVTMYFMMKGIDLTLWKHILMVVAMVVFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTLIQNVNPAAFGTMEWETDAEYARSLNAFLDTYAEKIGAK
IVVFVTEEELNTNFRGVRSQFSITVSPESIEQLNEQKAVQIENVGIIPAKIIKDVYIIMDGQKNNLQDRDFENVYNLTIH
HSYFCK

Download         Length: 741 bp

>T184151 NZ_CP087390:2281945-2282259 [Enterobacter sp. AN-K1]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4984.43 Da        Isoelectric Point: 3.9944

>AT184151 WP_012094285.1 NZ_CP066185:3095813-3095941 [Bacillus cytotoxicus]
VLKEYSNDFFKDEAEDTTDFSLIKGDTMQQVEELEEELKRRG

Download         Length: 129 bp

>AT184151 NZ_CP087390:2282256-2282675 [Enterobacter sp. AN-K1]
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGCCCCTTGCTGGATATTGTGT
GCGCCAGAATTAGCCATTTCGAAGCTAATCGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTTGGA
ATTGCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACTCTGAACCATATCAAAAAGCTGGCGGCCAGATTTGGGGTATCAC
CTGCGTTATTTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA7GPN6

Antitoxin

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Source
ID
Structure
AlphaFold DBA7GPN7

References