Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3152412..3153404 Replicon chromosome
Accession NZ_CP066184
Organism Bacillus cytotoxicus strain SM1.1

Toxin (Protein)


Gene name spoIISA Uniprot ID A7GPN6
Locus tag JC777_RS17085 Protein ID WP_012094283.1
Coordinates 3152664..3153404 (-) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A7GPN7
Locus tag JC777_RS17080 Protein ID WP_012094285.1
Coordinates 3152412..3152540 (-) Length 43 a.a.

Genomic Context

JC777_RS17065JC777_RS17070JC777_RS17105JC777_RS17055JC777_RS17060JC777_RS17075JC777_RS17080JC777_RS17085JC777_RS17090JC777_RS17095JC777_RS17100JC777_RS17110
Location: 3150533..3151414 (882 bp)
Type: Others
Protein ID: WP_012094288.1
Location: 3151455..3152000 (546 bp)
Type: Others
Protein ID: WP_087094926.1
Location: 3156676..3157005 (330 bp)
Type: Others
Protein ID: Protein_3154
Location: 3148017..3148268 (252 bp)
Type: Others
Protein ID: WP_012094290.1
Location: 3148858..3150327 (1470 bp)
Type: Others
Protein ID: WP_012094289.1
Location: 3152159..3152335 (177 bp)
Type: Others
Protein ID: WP_087094925.1
Location: 3152412..3152540 (129 bp)
Type: Antitoxin
Protein ID: WP_012094285.1
Location: 3152664..3153404 (741 bp)
Type: Toxin
Protein ID: WP_012094283.1
Location: 3153599..3154336 (738 bp)
Type: Others
Protein ID: WP_012094282.1
Location: 3154474..3154956 (483 bp)
Type: Others
Protein ID: WP_012094281.1
Location: 3155176..3156480 (1305 bp)
Type: Others
Protein ID: WP_087098711.1
Location: 3157029..3157931 (903 bp)
Type: Others
Protein ID: WP_087098709.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JC777_RS17055 (JC777_17060)3148017..3148268-252WP_012094290.1hypothetical protein-
JC777_RS17060 (JC777_17065)3148858..3150327-1470WP_012094289.1aminoacyl-histidine dipeptidase-
JC777_RS17065 (JC777_17070)3150533..3151414+882WP_012094288.1aminoglycoside 6-adenylyltransferase-
JC777_RS17070 (JC777_17075)3151455..3152000+546WP_087094926.1GNAT family N-acetyltransferase-
JC777_RS17075 (JC777_17080)3152159..3152335-177WP_087094925.1stage II sporulation protein SB-
JC777_RS17080 (JC777_17085)3152412..3152540-129WP_012094285.1hypothetical proteinAntitoxin
JC777_RS17085 (JC777_17090)3152664..3153404-741WP_012094283.1type II toxin-antitoxin system SpoIISA family toxinToxin
JC777_RS17090 (JC777_17095)3153599..3154336-738WP_012094282.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
JC777_RS17095 (JC777_17100)3154474..3154956-483WP_012094281.1helix-turn-helix domain-containing protein-
JC777_RS17100 (JC777_17105)3155176..3156480-1305WP_087098711.1DEAD/DEAH box helicase-
JC777_RS17105 (JC777_17110)3156676..3157005+330Protein_3154hypothetical protein-
JC777_RS17110 (JC777_17115)3157029..3157931-903WP_087098709.1BadF/BadG/BcrA/BcrD ATPase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28628.30 Da        Isoelectric Point: 6.7302

>T184149 WP_012094283.1 NZ_CP066184:c3153404-3152664 [Bacillus cytotoxicus]
MTVTSVRIGLFFLVIFFLFLIFFYWRNEERYEERKQLIRKTWYGLFITSVTMYFMMKGIDLTLWKHILMVVAMVVFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTLIQNVNPAAFGTMEWETDAEYARSLNAFLDTYAEKIGAK
IVVFVTEEELNTNFRGVRSQFSITVSPESIEQLNEQKAVQIENVGIIPAKIIKDVYIIMDGQKNNLQDRDFENVYNLTIH
HSYFCK

Download         Length: 741 bp

>T184149 NZ_CP087390:c1378052-1377642 [Enterobacter sp. AN-K1]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4984.43 Da        Isoelectric Point: 3.9944

>AT184149 WP_012094285.1 NZ_CP066184:c3152540-3152412 [Bacillus cytotoxicus]
VLKEYSNDFFKDEAEDTTDFSLIKGDTMQQVEELEEELKRRG

Download         Length: 129 bp

>AT184149 NZ_CP087390:c1378299-1378033 [Enterobacter sp. AN-K1]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA7GPN6

Antitoxin

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Source
ID
Structure
AlphaFold DBA7GPN7

References