Detailed information of TA system TA184145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/ElaA-DUF1778
• Location: 187701..188452
• Replicon: plasmid pKP2011790
• Accession: NZ_CP066174
• Organism: Klebsiella quasipneumoniae strain KP2011790

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: JDZ43_RS25230
• Protein ID: WP_048333033.1
• Coordinates: 187701..188183 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A071LPN3
• Locus tag: JDZ43_RS25235
• Protein ID: WP_004902250.1
• Coordinates: 188174..188452 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JDZ43_RS25210	184100..184747	-	648	WP_014386537.1	EcsC family protein	-
JDZ43_RS25215	184774..185529	-	756	WP_004902235.1	DUF2971 domain-containing protein	-
JDZ43_RS25220	185630..186022	-	393	WP_032442757.1	hypothetical protein	-
JDZ43_RS25225	186127..186666	-	540	WP_004902239.1	hypothetical protein	-
JDZ43_RS25230	187701..188183	-	483	WP_048333033.1	GNAT family N-acetyltransferase	Toxin
JDZ43_RS25235	188174..188452	-	279	WP_004902250.1	DUF1778 domain-containing protein	Antitoxin
JDZ43_RS25240	188574..188786	-	213	WP_016946198.1	hypothetical protein	-
JDZ43_RS25245	188894..189235	-	342	WP_032437747.1	hypothetical protein	-
JDZ43_RS25250	190141..190455	+	315	WP_023288299.1	hypothetical protein	-
JDZ43_RS25255	190699..191181	-	483	WP_172694439.1	hypothetical protein	-
JDZ43_RS25260	192603..193259	-	657	WP_023287188.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2	1..210864	210864

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-86)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17708.53 Da
• Isoelectric Point: 8.9130

>T184145 WP_048333033.1 NZ_CP066174:c188183-187701 [Klebsiella quasipneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Nucleotide

• Length: 483 bp

>T184145 NZ_CP087381:850263-850541 [Desulfovibrio subterraneus]
ATGATACGGAGCTTCGCACACAAAGGCCTTGAAGACCTGTTCTACGACGGCACAACCAAAGGCGTGCAGCAAAAGCATGT
ACGCAAGCTGCTGGATATTCTGGACAGGCTGGACCACGCGCGGGAAATCAGAGACATGAACTTTCCCGGCTCCGGCCTGC
ACCCGCTCAAAGGCGGACTTGCAGAACACTGGTCCGTCAAGGTTTCCGGCAACTGGCGAATTACCTTCCGCTTCGAAAAC
GGCGACGCCCATATCGTGAATTATCAGGACTACCACTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10704.23 Da
• Isoelectric Point: 4.5271

>AT184145 WP_004902250.1 NZ_CP066174:c188452-188174 [Klebsiella quasipneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Nucleotide

• Length: 279 bp

>AT184145 NZ_CP087381:850552-850854 [Desulfovibrio subterraneus]
ATGCGCACCCGCACCAGAAAGCCCACGCACCCGGGCGGCATCCTGTTCAGAATGCACATGGAGCCGCTGGGCATTACCAT
AACCGCACTGGCCAAGCGCCTTGGCATTTCGCGCAAGACGCTTTCCGCCATTGTGAACGAACGCGCGCCCATCACGCCGG
ACATTGCCCTGCGCCTTTCGCGCGCGCTCGATACCACGCCCGAACTCTGGCTTGGCATGCAGCAGACGTTTACACTGTGG
GAAGTTGCCCACTCCAATACGGAATGGCTTTCCGTGGAACCCATCAAGACTGCAAACGCATAG

Structures

Antitoxin

• AlphaFold DB: A0A071LPN3